Add to ORKGIt is known that central nervous system myelin contains proteolytic enzymes which degrade the myelin basic protein (MBP). We have found that zinc acetate is able to inhibit MBP cleavage at concentrations of 1 mM or higher. Furthermore, the Zn-inhibitable MBP-degrading activity was found to be water-soluble and able to recognize MBP also if this protein was protected by its lipidic environment in the native-like, lipid-bound form. Data presented here suggest a Zn-dependent metallo-protease which recognize MBP as a substrate probably even in the myelin sheath, when the protein is not yet released from the membrane
AbstractFor the first time x-ray absorption spectroscopy was used to investigate the Zn environment ...
AbstractMyelin basic protein (MBP) extracted from human delipidated white matter was found to be deg...
The botulinum neurotoxins (BoNT, serotypes A-G) are some of the most toxic proteins known and are th...
It is known that central nervous system myelin contains proteolytic enzymes which degrade the myelin...
Myelin Basic Protein (MBP) is a highly abundant protein in central nervous system (CNS) myelin that ...
In recent years there has been a wide interest toward zinc metalloproteases involved in neurodegener...
ABSTRACT For the first time x-ray absorption spectroscopy was used to investigate the Zn environment...
AbstractPurified human myelin was incubated with exogenous myelin basic protein (MBP) at pH 4.0 to s...
The data presented in this paper are consistent with the existence of a plasma membrane zinc/proton ...
For the first time x-ray absorption spectroscopy was used to investigate the Zn environment in Langm...
Our lab has previously demonstrated that multiple sclerosis-induced spinal cord white matter damage ...
For the first time x-ray absorption spectroscopy was used to investigate the Zn environment in Langm...
ii Transition metals have been suggested to play a pivotal role in the pathogenesis of numerous neur...
Zinc has been identifi ed as one of the most important minerals in the human body. As a trace elemen...
The interaction of myelin basic protein (MBP) with zinc and phosphate ions has been studied by using...
AbstractFor the first time x-ray absorption spectroscopy was used to investigate the Zn environment ...
AbstractMyelin basic protein (MBP) extracted from human delipidated white matter was found to be deg...
The botulinum neurotoxins (BoNT, serotypes A-G) are some of the most toxic proteins known and are th...
It is known that central nervous system myelin contains proteolytic enzymes which degrade the myelin...
Myelin Basic Protein (MBP) is a highly abundant protein in central nervous system (CNS) myelin that ...
In recent years there has been a wide interest toward zinc metalloproteases involved in neurodegener...
ABSTRACT For the first time x-ray absorption spectroscopy was used to investigate the Zn environment...
AbstractPurified human myelin was incubated with exogenous myelin basic protein (MBP) at pH 4.0 to s...
The data presented in this paper are consistent with the existence of a plasma membrane zinc/proton ...
For the first time x-ray absorption spectroscopy was used to investigate the Zn environment in Langm...
Our lab has previously demonstrated that multiple sclerosis-induced spinal cord white matter damage ...
For the first time x-ray absorption spectroscopy was used to investigate the Zn environment in Langm...
ii Transition metals have been suggested to play a pivotal role in the pathogenesis of numerous neur...
Zinc has been identifi ed as one of the most important minerals in the human body. As a trace elemen...
The interaction of myelin basic protein (MBP) with zinc and phosphate ions has been studied by using...
AbstractFor the first time x-ray absorption spectroscopy was used to investigate the Zn environment ...
AbstractMyelin basic protein (MBP) extracted from human delipidated white matter was found to be deg...
The botulinum neurotoxins (BoNT, serotypes A-G) are some of the most toxic proteins known and are th...