Ovarian cancer is the fourth most common cancer among women worldwide, leading to high mortality rates. Platinum anti-cancer drugs have been widely used in the treatment of ovarian cancers, but the development of resistance to these drugs is a rapidly growing impediment for their clinical use. Studies of the cell morphology using IncuCyte Zoom and HoloMonitor M4 have shown that A2780.CisR cells contained heterogeneous cell populations that partially underwent epithelial-to-mesenchymal transition (EMT). Mesenchymal A2780.CisR cells were likely to be more resistant to a cytotoxic natural killer (NKL) cell line, compared with the epithelial A2780 cells. Mesenchymal phenotype was associated with lower total Cu content and higher total Fe conten...
FDA-Pt () and markers for ATP7A and ATP7B (both ) in A2780 and A2780cis cells. , the structure is po...
Or Golgi and protein markers. Ovals indicate cell periphery. Scale bar, 10 μm.<p><b>Copyright inform...
Colorectal cancer (CRC) is a major health problem and cause of morbidity and mortality worldwide. Th...
The molecular mechanism of cisplatin uptake remains poorly defined and impaired drug accumulation ma...
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer negative for estrogen, p...
Objective: Ovarian cancer (OvCa) cells that are highly aggressive or possess cancer-stem-like proper...
Ells in the drug-free medium for 1 h. Cell nuclei were stained with propidium iodide (). Ovals indic...
The development of resistance to cisplatin (cDDP) is commonly accompanied by reduced drug uptake or ...
Labelled with LysoTracker™ Red (), cell nuclei were stained with Hoechst 33342 (). Ovals indicate ce...
Mammalian cells express two copper (Cu) influx transporters, CTR1 and CTR2. CTR1 serves as an influx...
Ells in the drug-free medium for 1 h. Cell nuclei were stained with propidium iodide (). Ovals indic...
BackgroundOvarian cancer (OC) is one of the most common and most malignant gynecological malignancie...
Platinum(Pt)-containing cancer drugs are highly polar molecules that do not diffuse across lipid mem...
Down-regulation of copper transporter 1 (CTR1) reduces up-take and sensitivity, whereas down-regulat...
Cisplatin, a commonly used chemotherapeutic, is limited on it efficacy due to the rapid development ...
FDA-Pt () and markers for ATP7A and ATP7B (both ) in A2780 and A2780cis cells. , the structure is po...
Or Golgi and protein markers. Ovals indicate cell periphery. Scale bar, 10 μm.<p><b>Copyright inform...
Colorectal cancer (CRC) is a major health problem and cause of morbidity and mortality worldwide. Th...
The molecular mechanism of cisplatin uptake remains poorly defined and impaired drug accumulation ma...
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer negative for estrogen, p...
Objective: Ovarian cancer (OvCa) cells that are highly aggressive or possess cancer-stem-like proper...
Ells in the drug-free medium for 1 h. Cell nuclei were stained with propidium iodide (). Ovals indic...
The development of resistance to cisplatin (cDDP) is commonly accompanied by reduced drug uptake or ...
Labelled with LysoTracker™ Red (), cell nuclei were stained with Hoechst 33342 (). Ovals indicate ce...
Mammalian cells express two copper (Cu) influx transporters, CTR1 and CTR2. CTR1 serves as an influx...
Ells in the drug-free medium for 1 h. Cell nuclei were stained with propidium iodide (). Ovals indic...
BackgroundOvarian cancer (OC) is one of the most common and most malignant gynecological malignancie...
Platinum(Pt)-containing cancer drugs are highly polar molecules that do not diffuse across lipid mem...
Down-regulation of copper transporter 1 (CTR1) reduces up-take and sensitivity, whereas down-regulat...
Cisplatin, a commonly used chemotherapeutic, is limited on it efficacy due to the rapid development ...
FDA-Pt () and markers for ATP7A and ATP7B (both ) in A2780 and A2780cis cells. , the structure is po...
Or Golgi and protein markers. Ovals indicate cell periphery. Scale bar, 10 μm.<p><b>Copyright inform...
Colorectal cancer (CRC) is a major health problem and cause of morbidity and mortality worldwide. Th...