Background In the last decades, the concept of metabolic rewiring as a cancer hallmark has been expanded beyond the "Warburg effect" and the importance of other metabolic routes, including lipid metabolism, has emerged. In cancer, lipids are not only a source of energy but are also required for the formation of membranes building blocks, signaling and post-translational modification of proteins. Since lipid metabolism contributes to the malignancy of cancer cells, it is an attractive target for therapeutic strategies. Methods Over-expression of the adipose triglyceride lipase (ATGL) was used to boost lipid catabolism in cervical cancer cells. The cervical cancer cell line HeLa was employed as the primary experimental model for all subsequen...
Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, c...
HRAS, NRAS and KRAS, collectively referred to as oncogenic RAS, are the most frequently mutated driv...
Evidence demonstrates the importance of lipid metabolism and signaling in cancer cell biology. De no...
Background In the last decades, the concept of metabolic rewiring as a cancer hallmark has been expa...
Although cancer cell metabolism was mainly considered to rely on glycolysis, with the concomitant im...
Although hypoxia has been shown to reprogram cancer cells toward glycolytic shift, the identity of e...
Clear cell renal cell carcinoma (ccRCC) is histologically defined by its lipid and glycogen-rich cyt...
Metabolic reprogramming is a typical feature of cancer cells aimed at sustaining high-energetic dema...
Among metabolic rearrangements occurring in cancer cells, lipid metabolism alteration has become a h...
Recent evidence established a link between disturbed lipid metabolism and increased risk for cancer....
Abstract Background Hypoxia signaling, especially the hypoxia inducible factor (HIF) pathway, is a m...
Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, c...
HRAS, NRAS and KRAS, collectively referred to as oncogenic RAS, are the most frequently mutated driv...
Evidence demonstrates the importance of lipid metabolism and signaling in cancer cell biology. De no...
Background In the last decades, the concept of metabolic rewiring as a cancer hallmark has been expa...
Although cancer cell metabolism was mainly considered to rely on glycolysis, with the concomitant im...
Although hypoxia has been shown to reprogram cancer cells toward glycolytic shift, the identity of e...
Clear cell renal cell carcinoma (ccRCC) is histologically defined by its lipid and glycogen-rich cyt...
Metabolic reprogramming is a typical feature of cancer cells aimed at sustaining high-energetic dema...
Among metabolic rearrangements occurring in cancer cells, lipid metabolism alteration has become a h...
Recent evidence established a link between disturbed lipid metabolism and increased risk for cancer....
Abstract Background Hypoxia signaling, especially the hypoxia inducible factor (HIF) pathway, is a m...
Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, c...
HRAS, NRAS and KRAS, collectively referred to as oncogenic RAS, are the most frequently mutated driv...
Evidence demonstrates the importance of lipid metabolism and signaling in cancer cell biology. De no...