Persistence of both reversible airway obstruction and higher blood eosinophils may predict lung function decline in severe asthma
- Sposato B.
- Scalese M.
- Ricci A.
- Rogliani P.
- Paggiaro P.
- Sposato B.
- Migliorini M. G.
- Di Tomassi M.
- Olivieri C.
- Perrella A.
- Camiciottoli G.
- Maselli R.
- Pelaia G.
- Busceti M. T.
- Sabato E.
- Cagnazzo M. G.
- Colombo F.
- Palumbo L.
- Ravazzi A.
- Bucca C.
- Caiaffa M. F.
- Berra A.
- Calabrese C.
- Stanziola A. A.
- Schino P.
- Di Gioacchino M.
- Rogliani P.
- Cazzola M.
- Segreti A.
- Pastorello E. A.
- Scibilia G.
- Vianello A.
- Marchi M. R.
- Paladini L.
- Baglioni S.
- Abbritti M.
- Almerigogna F.
- Matucci A.
- Vultaggio A.
- Maggi E.
- Maestrelli P.
- Guarnieri G.
- Steinhilber G.
- Bonavia M.
- Rottoli P.
- Bargagli E.
- Senna G.
- Caminati M.
- Macchia L.
- Bellia V.
- Scichilone N.
- Paggiaro P.
- Novelli F.
- Latorre M.
- Vergura L.
- Masieri S.
- Scalese M.
- Rosati Y.
- Milanese M.
- Folletti I.
- Pio R.
- Pio A.
- Maccari U.
- Maggiorelli C.
- Scala R.
- Vignale L.
- Pulera N.
- Carpagnano G. E.
- Foschino Barbaro M. P.
DOIAbstract
Objective This study analysed whether the persistence of both reversible airway obstruction (RAO) and elevated BE counts was associated to reduced asthma control and accelerated lung function decline in treated severe asthmatics.Methods About 202 severe asthmatics were studied after 12-120 months of step-5 treatment associated to anti-IgE therapy. Following treatments, reversibility tests, after inhaling 400 mcg of Salbutamol, were performed. FEV1 > 12% or <= 12% changes differentiated RAO+ from RAO- subjects. Blood eosinophil (BE) counts after treatment were considered.Results Pre-/post-treatment bronchodilator FEV1% and ACT were lower (61% [50-71], 74.4% [62.5-83.7] and 20[18-22]), whereas BE were higher (380 cells/mu l [170-590]) i...
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