The uncontrolled activation of the immune system toward antigens contained in the gut lumen in genetically predisposed subjects is believed to be the leading cause of inflammatory bowel disease (IBD). Two not mutually exclusive hypotheses can explain the pathogenic process leading to IBD. The first and mostly explored hypothesis states that the loss of tolerance toward gut microbiota antigens generates an aberrant inflammatory response that is perpetuated by continuous and unavoidable exposure to the triggering antigens. However, the discovery that the resolution of inflammation is not the mere consequence of clearing inflammatory triggers and diluting pro-inflammatory factors, but rather an active process in which molecular and cellular el...
Although strong protective immune response is essential for preventing invasion by pathogens, equiva...
Loss of intestinal immune regulation leading to aberrant immune responses to the commensal microbiot...
Despite all the advances in our understanding of the pathophysiology of inflammatory bowel disease (...
The uncontrolled activation of the immune system toward antigens contained in the gut lumen in genet...
The uncontrolled activation of the immune system toward antigens contained in the gut lumen in genet...
The uncontrolled activation of the immune system toward antigens contained in the gut lumen in genet...
In the last few decades, the pathogenesis of inflammatory bowel disease (IBD) in genetically predisp...
International audienceInflammatory bowel diseases (IBD) are idiopathic, chronic and relapsing inflam...
Formerly considered as a passive process, the resolution of acute inflammation is now recognized as ...
The gastrointestinal tract is the largest immune interface with the environment. Exposure to large n...
Formerly considered as a passive process, the resolution of acute inflammation is now recognized as ...
Inflammatory bowel disease (IBD) represents a difficult and challenging condition for patients, clin...
The incidence of chronic inflammatory and autoimmune diseases is steadily increasing. Inflammatory b...
Ulcerative colitis (UC) and Crohn's disease (CD), the primary constituents of inflammatory bowel dis...
In the last decade a number of models of chronic intestinal inflammation have been described that re...
Although strong protective immune response is essential for preventing invasion by pathogens, equiva...
Loss of intestinal immune regulation leading to aberrant immune responses to the commensal microbiot...
Despite all the advances in our understanding of the pathophysiology of inflammatory bowel disease (...
The uncontrolled activation of the immune system toward antigens contained in the gut lumen in genet...
The uncontrolled activation of the immune system toward antigens contained in the gut lumen in genet...
The uncontrolled activation of the immune system toward antigens contained in the gut lumen in genet...
In the last few decades, the pathogenesis of inflammatory bowel disease (IBD) in genetically predisp...
International audienceInflammatory bowel diseases (IBD) are idiopathic, chronic and relapsing inflam...
Formerly considered as a passive process, the resolution of acute inflammation is now recognized as ...
The gastrointestinal tract is the largest immune interface with the environment. Exposure to large n...
Formerly considered as a passive process, the resolution of acute inflammation is now recognized as ...
Inflammatory bowel disease (IBD) represents a difficult and challenging condition for patients, clin...
The incidence of chronic inflammatory and autoimmune diseases is steadily increasing. Inflammatory b...
Ulcerative colitis (UC) and Crohn's disease (CD), the primary constituents of inflammatory bowel dis...
In the last decade a number of models of chronic intestinal inflammation have been described that re...
Although strong protective immune response is essential for preventing invasion by pathogens, equiva...
Loss of intestinal immune regulation leading to aberrant immune responses to the commensal microbiot...
Despite all the advances in our understanding of the pathophysiology of inflammatory bowel disease (...