Porphyromonas gingivalis (Pg) is a keystone pathogen associated with chronic periodontitis and produces outer membrane vesicles (OMVs) that contain lipopolysaccharide (LPS), gingipains, and pathogen-derived DNA and RNA. Pg-OMVs are involved in the pathogenesis of periodontitis. Pg-OMV-activated pathways that induce the production of the pro-inflammatory cytokines, interleukin (IL)-6, and IL-8 in the human gingival epithelial cell line, OBA-9, were investigated. The role of mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB in levels of Pg-OMV-induced pro-inflammatory cytokines was investigated using Western blot analysis and specific pathway inhibitors. Pg-OMVs induced IL-6 and IL-8 production via the extracellular signal-re...
Periodontitis is increasingly associated with increased risk of cardiovascular and other systemic di...
Porphyromonas gingivalis is a keystone oral pathogen that successfully manipulates the human innate ...
Objective: Periodontal disease is accompanied by inflammation of the gingiva and destruction of peri...
AbstractBackground/purposeVarious toxic products are generated by periodontal pathogens. Porphyromon...
Porphyromonas gingivalis is a keystone periodontopathogen and its lipopolysacharide (LPS) is strongl...
Periodontitis is a chronic inflammatory disease caused by bacterial invasion of the gingival epithe...
Periodontal diseases, the major public health problem of the oral cavity, are clinically characteriz...
Abstract Background The bacter...
Objectives: Infection of epithelial cells with Porphyromonas gingivalis (Pg) results in production o...
Periodontal diseases result from the interplay between the dysregulation of the host inflammatory re...
To investigate whether oligomerization domains (NODs) are involved in Porphyromonas gingivalis-induc...
Porphyromonas gingivalis lipopolysaccharide (LPS) (strain W50) interacts with Toll-like receptor 2 (...
Objectives: Infection of epithelial cells with Porphyromonas gingivalis (Pg) results in production ...
Objective: Porphyromonas gingivalis lipopolysaccharide (PgLPS) is a crucial virulence factor strongl...
Objectives: The periodontopathogen Porphyromonas gingivalis (Pg) adheres to, invades and replicates ...
Periodontitis is increasingly associated with increased risk of cardiovascular and other systemic di...
Porphyromonas gingivalis is a keystone oral pathogen that successfully manipulates the human innate ...
Objective: Periodontal disease is accompanied by inflammation of the gingiva and destruction of peri...
AbstractBackground/purposeVarious toxic products are generated by periodontal pathogens. Porphyromon...
Porphyromonas gingivalis is a keystone periodontopathogen and its lipopolysacharide (LPS) is strongl...
Periodontitis is a chronic inflammatory disease caused by bacterial invasion of the gingival epithe...
Periodontal diseases, the major public health problem of the oral cavity, are clinically characteriz...
Abstract Background The bacter...
Objectives: Infection of epithelial cells with Porphyromonas gingivalis (Pg) results in production o...
Periodontal diseases result from the interplay between the dysregulation of the host inflammatory re...
To investigate whether oligomerization domains (NODs) are involved in Porphyromonas gingivalis-induc...
Porphyromonas gingivalis lipopolysaccharide (LPS) (strain W50) interacts with Toll-like receptor 2 (...
Objectives: Infection of epithelial cells with Porphyromonas gingivalis (Pg) results in production ...
Objective: Porphyromonas gingivalis lipopolysaccharide (PgLPS) is a crucial virulence factor strongl...
Objectives: The periodontopathogen Porphyromonas gingivalis (Pg) adheres to, invades and replicates ...
Periodontitis is increasingly associated with increased risk of cardiovascular and other systemic di...
Porphyromonas gingivalis is a keystone oral pathogen that successfully manipulates the human innate ...
Objective: Periodontal disease is accompanied by inflammation of the gingiva and destruction of peri...