Noncaseating Granulomatous Disease in Common Variable Immunodeficiency

Patients with common variable immunodeficiency (CVID) are occasionally recognized to have a concurrent noncaseating granulomatous disease. The granulomatous disease (GD) associated with CVID shares many clinical properties typical of sarcoidosis. Some investigators speculate that the GD-CVID is actually sarcoidosis that is expressed atypically because of the patient\u27s immunodeficiency. Clinical differences, however, have led other investigators to speculate that the GD-CVID is a distinct sarcoid-like granulomatous process