Continuous manufacturing, a trend for the production of biopharmaceuticals, holds significant promise for achieving higher productivity and lower cost. Next generation cell culture perfusion processes are among the most sought after to deliver on this promise. While the concept of continuous cell culture is not new, hurdles in the robustness and consistency of cell retention devices slow current adoption. The inherent lot-to-lot variability in commercially available hollow-fiber membrane (HFMs) often requires operators to adjust process parameters during the course of the perfusion process. Reproducible process intensification using HFM devices for cell retention requires membranes with consistent flux (LMH), bubble point (BP), and effectiv...
Groups in both industry and academia have achieved high densities and productivities in perfusion ce...
The maturation of biopharmaceutical process understanding and technical advances have paved the way ...
Process intensification leveraging perfusion offers immense opportunities for yield improvement over...
Continuous production of biologics, a growing trend in the biopharmaceutical industry, requires a re...
Integrated continuous biomanufacturing has gained significant interest because of its potential to s...
Manufacturers of therapeutic proteins are becoming increasingly interested in continuous bioprocessi...
In newly developed Biogen manufacturing processes, we are using perfusion technology to shift the ce...
The feasibility of ex vivo blood production is limited by both biological and engineering challenges...
Traditionally, perfusion processes using either TFF or ATF technologies have utilized hollow fibers ...
Tissue vasculature efficiently distributes nutrients, removes metabolites, and possesses selective c...
Tissue vasculature efficiently distributes nutrients, removes metabolites, and possesses selective c...
Perfusion cell culture processes provide opportunities to increase product yield through improved ce...
Perfusion operation mode is currently under fast expansion in mammalian cell based manufacturing of ...
Continuous manufacturing has been investigated in both academia and industry as an alternative to ba...
Perfusion processes have traditionally been used for the generation of unstable proteins in cell cul...
Groups in both industry and academia have achieved high densities and productivities in perfusion ce...
The maturation of biopharmaceutical process understanding and technical advances have paved the way ...
Process intensification leveraging perfusion offers immense opportunities for yield improvement over...
Continuous production of biologics, a growing trend in the biopharmaceutical industry, requires a re...
Integrated continuous biomanufacturing has gained significant interest because of its potential to s...
Manufacturers of therapeutic proteins are becoming increasingly interested in continuous bioprocessi...
In newly developed Biogen manufacturing processes, we are using perfusion technology to shift the ce...
The feasibility of ex vivo blood production is limited by both biological and engineering challenges...
Traditionally, perfusion processes using either TFF or ATF technologies have utilized hollow fibers ...
Tissue vasculature efficiently distributes nutrients, removes metabolites, and possesses selective c...
Tissue vasculature efficiently distributes nutrients, removes metabolites, and possesses selective c...
Perfusion cell culture processes provide opportunities to increase product yield through improved ce...
Perfusion operation mode is currently under fast expansion in mammalian cell based manufacturing of ...
Continuous manufacturing has been investigated in both academia and industry as an alternative to ba...
Perfusion processes have traditionally been used for the generation of unstable proteins in cell cul...
Groups in both industry and academia have achieved high densities and productivities in perfusion ce...
The maturation of biopharmaceutical process understanding and technical advances have paved the way ...
Process intensification leveraging perfusion offers immense opportunities for yield improvement over...