The Effect of Rambutan (Nephelium Lappaceum L.) Peel Extract on Lipid Peroxidation in Liver of Obese Rats

Lipid accumulation is main cause of obesity which then may cause liver damage due to a high oxidative stress. The oxidative stress in cell can cause lipid peroxidation. This process can be prevented by giving the external antioxidants. Previous study reported that rambutan peel extract reduced mice body weight and several adipogenesis parameters in visceral lipid. The objective of this research was to study the effect of rambutan peel extract on lipid peroxidation and accumulation in the liver of obese rats. The research was arranged in a complete randomized design (CRD). The experimental animals used were male Wistar rat aged 13 weeks weighed 310-340 gram which grouped into 5 groups; each group was given 15mg/kgbw, 30mg/kgbw, 60mg/kgbw, distilled water (C+), or nothing (C-). The extract was given per oral once every two days. The observed parameter are MDA levels and PPAR. expression. At week 12th the animals were dissected, the liver were isolated and tested for Malondialdehyde (MDA) level using TBA and PPARã expression using Immunohistochemistry. Data was analyzed using One Way ANOVA. The results showed that rambutan peel extract in 15 and 30mg/kgbw significantly decrease MDA levels and not significantly down regulate the expression of PPAR.