Purpose The purpose of this study was to measure the anti-angiogenic effect of N-desulfated Re–N-acetylated, a chemically modified heparin (mHep). Methods In vitro assays (cell tube formation, viability, proliferation, and migration) with endothelial cells were performed after 24 h of treatment with mHep at 10, 100, and 1000 ng/mL or saline. In vivo tests were performed after laser-induced choroidal neovascularization (CNV) in rats, followed by an intravitreal injection (5 µL) of mHep (10, 100, 1000 ng/mL) or balanced salt solution. Immunofluorescence analysis of the CNV was performed after 14 days. Results mHep produced a statistically significant reduction in cell proliferation, tube formation, and migration, without cell viability change...
Objective To investigate the role and underlying mechanism of 5α-hydroxycostic acid (5α-HA) in inhib...
Orally absorbable anticancer medications have great advantages for conventional cancer therapies to ...
Angiogenesis is the process of generating new capillary blood vessels. Uncontrolled endothelial cell...
Purpose The purpose of this study was to measure the anti-angiogenic effect of N-desulfated Re–N-ace...
Histone deacetylase (HDAC) is a key enzyme regulating gene expression, including angiogenic cytokine...
Purpose: Pathological fundus angiogenesis is a major cause of vision loss in retina diseases. Endost...
Introdução: A angiogênese, formação de novos vasos sanguíneos a partir de uma vasculatura preexisten...
Pathological fundus angiogenesis is a major cause of vision loss in retina diseases. Endostatin, a C...
<div><p>Purpose</p><p>Pathological fundus angiogenesis is a major cause of vision loss in retina dis...
Indiana University-Purdue University Indianapolis (IUPUI)Choroidal neovascularization (CNV) is the v...
The purpose of this study was to evaluate the inhibitory activity of the heparan sulfate suleparoide...
AIM: To study the effects of cytokeratin 17 (CK17) on sodium iodate (NaIO3) induced rat retinal pigm...
Angiogenesis is the process of generating new capillary blood vessels. Uncontrolled endothelial cell...
Vascularization of the cornea occurs in many pathological conditions and can result in loss of visua...
Heparin is widely used as an anticoagulant agent in clinical medication. Recent studies have reporte...
Objective To investigate the role and underlying mechanism of 5α-hydroxycostic acid (5α-HA) in inhib...
Orally absorbable anticancer medications have great advantages for conventional cancer therapies to ...
Angiogenesis is the process of generating new capillary blood vessels. Uncontrolled endothelial cell...
Purpose The purpose of this study was to measure the anti-angiogenic effect of N-desulfated Re–N-ace...
Histone deacetylase (HDAC) is a key enzyme regulating gene expression, including angiogenic cytokine...
Purpose: Pathological fundus angiogenesis is a major cause of vision loss in retina diseases. Endost...
Introdução: A angiogênese, formação de novos vasos sanguíneos a partir de uma vasculatura preexisten...
Pathological fundus angiogenesis is a major cause of vision loss in retina diseases. Endostatin, a C...
<div><p>Purpose</p><p>Pathological fundus angiogenesis is a major cause of vision loss in retina dis...
Indiana University-Purdue University Indianapolis (IUPUI)Choroidal neovascularization (CNV) is the v...
The purpose of this study was to evaluate the inhibitory activity of the heparan sulfate suleparoide...
AIM: To study the effects of cytokeratin 17 (CK17) on sodium iodate (NaIO3) induced rat retinal pigm...
Angiogenesis is the process of generating new capillary blood vessels. Uncontrolled endothelial cell...
Vascularization of the cornea occurs in many pathological conditions and can result in loss of visua...
Heparin is widely used as an anticoagulant agent in clinical medication. Recent studies have reporte...
Objective To investigate the role and underlying mechanism of 5α-hydroxycostic acid (5α-HA) in inhib...
Orally absorbable anticancer medications have great advantages for conventional cancer therapies to ...
Angiogenesis is the process of generating new capillary blood vessels. Uncontrolled endothelial cell...