Human-induced climate change is already affecting every inhabited region of the planet. Yet, over 90% of the excess heat associated with human activities has been absorbed by the ocean since the 1970s, which acts to largely damp atmospheric warming, but has large impacts on human societies and marine life. In this thesis, I explore when and where thermohaline changes in the ocean interior become large enough to be unambiguously set apart from internal variability and investigate their associated physical drivers, using ensembles of climate models and dedicated numerical experiments. We find that the climate signal in the upper ocean water-masses emerges between the late 20th century and the first decades of the 21st. The Southern Hemisphere...