To offer total smart life solutions in the immediate future, millions of sensors will be embedded into cities, vehicles, homes, industries, foods, toys, and other environments. Hence, it is imperative to develop advanced communication techniques that can support these applications. In order to realize the desired goals, spectrum-energy efficiency, wireless network security and high mobility communications are critical issues to facilitate ubiquitous wireless deployments. In this thesis, we address these challenges under various practical scenarios to ensure superior performance of next-generation wireless communication systems.In the first part, we focus on the energy-constrained networks and develop efficient strategies to enhance spectrum...