Improving ciprofloxacin antimicrobial activity through lipid nanoencapsulation or non-thermal plasma on Pseudomonas aeruginosa biofilms
- Muraca, Giuliana Sabrina
- Soler Arango, Juliana
- Castro, Guillermo Raul
- Islan, German Abel
- Brelles Mariño, Graciela
DOIAbstract
Antibiotic resistance is a significant challenge in the clinical practice. Pseudomonas aeruginosa is a multidrug-resistant opportunistic pathogen prevalent in hospital settings. Besides, P. aeruginosa forms biofilms that aggravate the problem since biofilms are more resilient to conventional decontamination methods than their planktonic counterparts. Due to the lack of novel antibiotics, the emergence of multidrug-resistant strains, and the resilience of biofilms to antimicrobials, new approaches based on the combination of agents are desirable. Non-thermal plasma (NTP) and nanotechnology-based strategies are an alternative to conventional decontamination/sterilization methods. NTP causes microbial cell damage or death, and it has been prov...
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