Circulating heat shock protein 27 (HSPB1) levels in prediction of pre-eclampsia: A pilot study
- Martin Varas, Raquel de Lourdes
- Sottile Fleury, Mayra Lis
- Redondo, Analia Lourdes
- Gomez, Laura Constanza
- Gauna, Gisel V.
- Flamini, Marina Ines
- Grajeda, Carina
- Anzalone, Alfonsa C.
- Rodriguez Echandia, Eduardo Luciano
- Nadin, Silvina Beatriz
- Vargas Roig, Laura Maria
DOIAbstract
Objective: To determine whether circulating heat shock proteins HSP27/HSPB1 and HSP90α/HSPC1 may be useful for early prediction of the occurrence of pre-eclampsia in asymptomatic women. Methods: We have measured by ELISA the levels of HSPB1, HSPC1, and placental protein 13 (PP13) in serum samples from 44 women in the first trimester (10–12 weeks) and second trimester (17–20 weeks) of pregnancy. Western blot and immunohistochemistry for HSPB1 and HSPC1 were performed. Results: HSPB1 serum levels were higher in women with pre-eclampsia than in normotensive pregnant women at the first and second trimester (P = 0.003), whereas PP13 levels decreased in women with pre-eclampsia only in the first trimester of gestation (P = 0.021). We also observe...
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