Over 90% of deaths in cancer patients are attributed to tumor drug resistance. Resistance to therapeutic agents can be due to an innate property of cancer cells or can be acquired during chemotherapy. In recent years, it has become increasingly clear that regulation of membrane ion channels is an important mechanism in the development of chemoresistance. Here, we review the contribution of ion channels in drug resistance of various types of cancers, evaluating their potential in clinical management. Several molecular mechanisms have been proposed, including evasion of apoptosis, cell cycle arrest, decreased drug accumulation in cancer cells, and activation of alternative escape pathways such as autophagy. Each of these mechanisms leads to a...
Pancreatic ductal adenocarcinoma is a devastating disease with a dismal prognosis. Therapeutic inter...
AbstractCancer is a disease with marked heterogeneity in both response to therapy and survival. Clin...
Early detection and treatment of cancers have increased survival and improved clinical outcome. The ...
Over 90% of deaths in cancer patients are attributed to tumor drug resistance. Resistance to therape...
In the battle against cancer cells, therapeutic modalities are drastically limited by intrinsic or a...
Ovarian cancer (OC) is the deadliest gynecologic cancer, due to late diagnosis, development of plati...
AbstractIon channels have been shown to be involved in oncogenesis and efforts are being poured in t...
Breast cancer consists of an assortment of illness and therapeutic failure is mostly due to the comp...
International audienceAngiogenesis is a finely tuned process, which is the result of the equilibrium...
AbstractApoptosis, a type of genetically controlled cell death, is a fundamental cellular mechanism ...
International audienceCancer is one of the leading causes of mortality in the world. This is a compl...
Pancreatic ductal adenocarcinoma is a devastating disease with a dismal prognosis. Therapeutic inter...
AbstractCancer is a disease with marked heterogeneity in both response to therapy and survival. Clin...
Early detection and treatment of cancers have increased survival and improved clinical outcome. The ...
Over 90% of deaths in cancer patients are attributed to tumor drug resistance. Resistance to therape...
In the battle against cancer cells, therapeutic modalities are drastically limited by intrinsic or a...
Ovarian cancer (OC) is the deadliest gynecologic cancer, due to late diagnosis, development of plati...
AbstractIon channels have been shown to be involved in oncogenesis and efforts are being poured in t...
Breast cancer consists of an assortment of illness and therapeutic failure is mostly due to the comp...
International audienceAngiogenesis is a finely tuned process, which is the result of the equilibrium...
AbstractApoptosis, a type of genetically controlled cell death, is a fundamental cellular mechanism ...
International audienceCancer is one of the leading causes of mortality in the world. This is a compl...
Pancreatic ductal adenocarcinoma is a devastating disease with a dismal prognosis. Therapeutic inter...
AbstractCancer is a disease with marked heterogeneity in both response to therapy and survival. Clin...
Early detection and treatment of cancers have increased survival and improved clinical outcome. The ...