Miltefosine (MIL)–allopurinol combination therapy administered at standard dosage is effective to treat canine leishmaniosis, nevertheless for some dogs the digestive tolerance of MIL is not acceptable. This study evaluates an alternative therapeutic protocol by using a modified dosage of MIL to increase its effectiveness and improve the digestive tolerance. Thirty-four Leishmania infantum owned naturally infected dogs were included and monitored for 180 days. The dogs were allocated in two randomized groups: Group X−18 dogs treated with MIL registered dose of 2 mg/kg, oral administration, once daily, for 28 days; Group Y−16 dogs treated with 1.2 mg/kg for 5 days followed by 2.5 mg/kg for 25 days. Both groups were also treated with allopuri...
<div><p>Background</p><p>Visceral leishmaniasis caused by the protozoan <i>Leishmania infantum</i> i...
Leishmaniasis is a complex disease caused by parasitic protozoans which are transmitted to a suscept...
Leishmaniosis due to Leishmania infantum (Syn: L. chagasi) is one of the most common diseases of dog...
Miltefosine (MIL)–allopurinol combination therapy administered at standard dosage is effective to tr...
Visceral leishmaniosis is a potentially life-threatening illness caused by a protozoan parasite of t...
The aim of this trial was to evaluate the effectiveness and safety of miltefosine-allopurinol combin...
Visceral leishmaniosis is a life-threatening disease of medical, social and economic importance in e...
The aim of the present paper was to evaluate the anti-Leishmania activity of 3 different protocols o...
Aim: The aim of this study was to evaluate changes in proteinuria in dogs naturally infected with vi...
BACKGROUND: In Europe most dogs with clinical leishmaniosis are treated with leishmanicides, typical...
Leishmaniasis is a tropical and subtropical disease caused by an intracellular protozoan transmitted...
Research Areas: Veterinary SciencesCanine leishmaniosis (CanL) caused by Leishmania infantum is a zo...
Canine leishmaniasis usually is treated with antimony compounds, but frequent relapses, adverse effe...
Two dogs, with naturally acquired canine leishmaniasis, were treated orally with miltefosine (2mg/kg...
Research Areas: Immunology ; Microbiology ; Veterinary SciencesXanthinuria is a significant adverse ...
<div><p>Background</p><p>Visceral leishmaniasis caused by the protozoan <i>Leishmania infantum</i> i...
Leishmaniasis is a complex disease caused by parasitic protozoans which are transmitted to a suscept...
Leishmaniosis due to Leishmania infantum (Syn: L. chagasi) is one of the most common diseases of dog...
Miltefosine (MIL)–allopurinol combination therapy administered at standard dosage is effective to tr...
Visceral leishmaniosis is a potentially life-threatening illness caused by a protozoan parasite of t...
The aim of this trial was to evaluate the effectiveness and safety of miltefosine-allopurinol combin...
Visceral leishmaniosis is a life-threatening disease of medical, social and economic importance in e...
The aim of the present paper was to evaluate the anti-Leishmania activity of 3 different protocols o...
Aim: The aim of this study was to evaluate changes in proteinuria in dogs naturally infected with vi...
BACKGROUND: In Europe most dogs with clinical leishmaniosis are treated with leishmanicides, typical...
Leishmaniasis is a tropical and subtropical disease caused by an intracellular protozoan transmitted...
Research Areas: Veterinary SciencesCanine leishmaniosis (CanL) caused by Leishmania infantum is a zo...
Canine leishmaniasis usually is treated with antimony compounds, but frequent relapses, adverse effe...
Two dogs, with naturally acquired canine leishmaniasis, were treated orally with miltefosine (2mg/kg...
Research Areas: Immunology ; Microbiology ; Veterinary SciencesXanthinuria is a significant adverse ...
<div><p>Background</p><p>Visceral leishmaniasis caused by the protozoan <i>Leishmania infantum</i> i...
Leishmaniasis is a complex disease caused by parasitic protozoans which are transmitted to a suscept...
Leishmaniosis due to Leishmania infantum (Syn: L. chagasi) is one of the most common diseases of dog...