Gene therapy can be described as the direct transfer of genetic material to cells or tissue for the treatment of inherited and acquired diseases. Viral vectors have long been proven to be the most efficient and stable vectors for transgene delivery into the cell, but they still have some safety issues. Non-viral nanosystems can overcome these safety problems and limitations of viral vectors. FDA-approved polymers are particularly attractive for gene delivery applications. Here, sustained release of plasmid DNA encoding the EGFP protein, used as a model, showed efficient delivery through new capsid-like biodegradable polyglycolic acid (PGA) nanoparticles (NPs). PGA NPs showed a mean size of 135 nm, with a polyhedron structure. Prior to loadi...
Thesis (Master's)--University of Washington, 2023Gene therapy, a promising and emerging medical appr...
Abstract Efficient delivery of genetic material to primary cells remains challenging. Here, efficie...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2007.Includ...
Gene therapy can be described as the direct transfer of genetic material to cells or tissue for the ...
After decades of pre-clinical and clinical research, gene therapies are finally achieving clinical s...
DoctorSuccessful gene therapy must cater the safety concern and in this aspect the non-viral polymer...
Extracellular and intracellular barriers typically prevent non-viral gene vectors from having an eff...
Biodegradable polymeric nanoparticles have the potential to be safer alternatives to viruses for gen...
Copyright © 2012 Jose ́ M. Morachis et al. This is an open access article distributed under the Crea...
Successful non-viral gene therapy is driven by the molecular makeup and architecture of the gene vec...
Extracellular and intracellular barriers typically prevent the efficient transfection of non-viral g...
Therapeutics based on nucleic acids offer the possibility of specific and potent treatment of diseas...
While DNA and messenger RNA (mRNA) based therapies are currently changing the biomedical field, thed...
Nucleic acids are expected as novel effective medicines, although they require a drug delivery syste...
Gene therapy is a suitable alternative to chemotherapy due to the complications of drug resistance a...
Thesis (Master's)--University of Washington, 2023Gene therapy, a promising and emerging medical appr...
Abstract Efficient delivery of genetic material to primary cells remains challenging. Here, efficie...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2007.Includ...
Gene therapy can be described as the direct transfer of genetic material to cells or tissue for the ...
After decades of pre-clinical and clinical research, gene therapies are finally achieving clinical s...
DoctorSuccessful gene therapy must cater the safety concern and in this aspect the non-viral polymer...
Extracellular and intracellular barriers typically prevent non-viral gene vectors from having an eff...
Biodegradable polymeric nanoparticles have the potential to be safer alternatives to viruses for gen...
Copyright © 2012 Jose ́ M. Morachis et al. This is an open access article distributed under the Crea...
Successful non-viral gene therapy is driven by the molecular makeup and architecture of the gene vec...
Extracellular and intracellular barriers typically prevent the efficient transfection of non-viral g...
Therapeutics based on nucleic acids offer the possibility of specific and potent treatment of diseas...
While DNA and messenger RNA (mRNA) based therapies are currently changing the biomedical field, thed...
Nucleic acids are expected as novel effective medicines, although they require a drug delivery syste...
Gene therapy is a suitable alternative to chemotherapy due to the complications of drug resistance a...
Thesis (Master's)--University of Washington, 2023Gene therapy, a promising and emerging medical appr...
Abstract Efficient delivery of genetic material to primary cells remains challenging. Here, efficie...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2007.Includ...