Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
- Lindgren, C. M
- Heid, I. M
- Randall, J. C
- Lamina, C
- Steinthorsdottir, V
- Qi, L
- Speliotes, E. K
- Thorleifsson, G
- Willer, C. J
- Herrera, B. M
- Jackson, A. U
- Lim, N
- Scheet, P
- Soranzo, N
- Amin, N
- Aulchenko, Y. S
- Chambers, J. C
- Drong, A
- Luan, J
- Lyon, H. N
- Rivadeneira, F
- Sanna, S
- Timpson, N. J
- Zillikens, M. C
- Jing, H. Z
- Almgren, P
- Bandinelli, S
- Bennett, A. J
- Bergman, R. N
- Bonnycastle, L. L
- Bumpstead, S. J
- Chanock, S. J
- Cherkas, L
- Chines, P
- Coin, L
- Cooper, C
- Crawford, G
- Doering, A
- Dominiczak, A
- Doney, A. S. F
- Ebrahim, S
- Elliott, P
- Erdos, M. R
- Estrada, K
- Ferrucci, L
- Fischer, G
- Forouhi, N. G
- Gieger, C
- Grallert, H
- Groves, C. J
- Grundy, S
- Guiducci, C
- Hadley, D
- Hamsten, A
- Havulinna, A. S
- Hofman, A
- Holle, R
- Holloway, J. W
- Illig, T
- Isomaa, B
- Jacobs, L. C
- Jameson, K
- Jousilahti, P
- Karpe, F
- Kuusisto, J
- Laitinen, J
- Lathrop, G. M
- Lawlor, D. A
- Mangino, M
- McArdle, W. L
- Meitinger, T
- Morken, M. A
- Morris, A. P
- Munroe, P
- Narisu, N
- Nordström, A
- Nordström, P
- Oostra, B. A
- Palmer, C. N. A
- Payne, F
- Peden, J. F
- Prokopenko, I
- Renström, F
- Ruokonen, A
- Salomaa, V
- Sandhu, M. S
- Scott, L. J
- Scuteri, A
- Silander, K
- Song, K
- Yuan, X
- Stringham, H. M
- Swift, A. J
- Tuomi, T
- Uda, M
- Vollenweider, P
- Waeber, G
- Wallace, C
- Walters, G. B
- Weedon, M. N
- Witteman, J. C. M
- Zhang, C
- Zhang, W
- Caulfield, M. J
- Collins, F. S
- Smith, G. D
- Day, I. N. M
- Franks, P. W
- Hattersley, A. T
- Hu, F. B
- Jarvelin, M. -R
- Kong, A
- Kooner, J. S
- Laakso, M
- Lakatta, E
- Mooser, V
- Morris, A. D
- Peltonen, L
- Samani, N. J
- Spector, T. D
- Strachan, D. P
- Tanaka, T
- Tuomilehto, J
- Uitterlinden, A. G
- Van Duijn, C. M
- Wareham, N. J
- Watkins, H
- Waterworth, D. M
- Boehnke, M
- Deloukas, P
- Groop, L
- Hunter, D. J
- Thorsteinsdottir, U
- Schlessinger, D
- Wichmann, H. -E
- Frayling, T. M
- Abecasis, G. R
- Hirschhorn, J. N
- Loos, R. J. F
- Stefansson, K
- Mohlke, K. L
- Barroso, I
- McCarthy, M. I
DOIAbstract
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9×102 -11) and MSRA (WC, P = 8.9×10-9). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6×10 -8). The variants near TFAP2B appear ...
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