Molecular communication technology: General considerations on the use of synthetic cells and some hints from in silico modelling

Recent advancements in synthetic biology pave the way to the design and construction of synthetic cells of increasing complexity, capable of performing specific functions in programmable manner. One of the most exciting goal is the development of a molecular communication technology based on the exchange of chemical signals between synthetic and natural cells. We are currently involved in such a research program. Following our previous contributions to WIVACE workshops (2012–2013), here we present the project, and discuss some general considerations on the use of synthetic cells for developing novel bio-chemical Information and Communication Technologies (bio-chem-ICTs). Moreover, by analysing in detail a mathematical model of synthetic cell/natural cell communication process, we provide some hints that can be valuable for the next experimental steps