Cancer chemotherapy can significantly impair the bone formation and cause myelosuppression; however, their recovery potentials and mechanisms remain unclear. This study investigated the roles of the β-catenin signaling pathway in bone and bone marrow recovery potentials in rats treated with antimetabolite methotrexate (MTX) (five once-daily injections, 0.75 mg/kg) with/without β-catenin inhibitor indocyanine green (ICG)-001 (oral, 200 mg/kg/day). ICG alone reduced trabecular bone volume and bone marrow cellularity. In MTX-treated rats, ICG suppressed bone volume recovery on Day 11 after the first MTX injection. ICG exacerbated MTX-induced decreases on Day 9 osteoblast numbers on bone surfaces, their formation in vitro from bone marrow strom...
The advancement and intensive use of chemotherapy in treating childhood cancers has led to a growing...
Intensive cancer chemotherapy is known to cause bone defects, which currently lack treatments. This ...
Intensive cancer chemotherapy is known to cause bone defects, which currently lack treatments. This ...
Cancer chemotherapy can significantly impair the bone formation and cause myelosuppression; however,...
Cancer chemotherapy can significantly impair the bone formation and cause myelosuppression; however,...
Cancer chemotherapy often causes significant bone loss, marrow adiposity and haematopoietic defects,...
The bone marrow microenvironment is home to mesenchymal and haematopoietic stem cells and their resp...
Intensive use of cancer chemotherapy is increasingly linked with long-term skeletal side effects suc...
Intensive cancer chemotherapy leads to significant bone loss, the underlying mechanism of which rema...
Cancer chemotherapy disrupts the bone marrow (BM) microenvironment affecting steady-state proliferat...
Crown copyright © 2007 Published by Elsevier Inc.Methotrexate (MTX) is a commonly used anti-metaboli...
Cancer chemotherapy with methotrexate (MTX) is known to cause bone loss. However, the underlying mec...
Chemotherapy-induced bone damage is a frequent side effect which causes diminished bone mineral dens...
Intensive cancer chemotherapy is known to cause bone defects, which currently lack treatments. This ...
Chemotherapy-induced bone damage is a frequent side effect which causes diminished bone mineral dens...
The advancement and intensive use of chemotherapy in treating childhood cancers has led to a growing...
Intensive cancer chemotherapy is known to cause bone defects, which currently lack treatments. This ...
Intensive cancer chemotherapy is known to cause bone defects, which currently lack treatments. This ...
Cancer chemotherapy can significantly impair the bone formation and cause myelosuppression; however,...
Cancer chemotherapy can significantly impair the bone formation and cause myelosuppression; however,...
Cancer chemotherapy often causes significant bone loss, marrow adiposity and haematopoietic defects,...
The bone marrow microenvironment is home to mesenchymal and haematopoietic stem cells and their resp...
Intensive use of cancer chemotherapy is increasingly linked with long-term skeletal side effects suc...
Intensive cancer chemotherapy leads to significant bone loss, the underlying mechanism of which rema...
Cancer chemotherapy disrupts the bone marrow (BM) microenvironment affecting steady-state proliferat...
Crown copyright © 2007 Published by Elsevier Inc.Methotrexate (MTX) is a commonly used anti-metaboli...
Cancer chemotherapy with methotrexate (MTX) is known to cause bone loss. However, the underlying mec...
Chemotherapy-induced bone damage is a frequent side effect which causes diminished bone mineral dens...
Intensive cancer chemotherapy is known to cause bone defects, which currently lack treatments. This ...
Chemotherapy-induced bone damage is a frequent side effect which causes diminished bone mineral dens...
The advancement and intensive use of chemotherapy in treating childhood cancers has led to a growing...
Intensive cancer chemotherapy is known to cause bone defects, which currently lack treatments. This ...
Intensive cancer chemotherapy is known to cause bone defects, which currently lack treatments. This ...