Based on related data as observed in Rgyalrong, this paper examines a phenomenon Watters (2004) and Prins (2016) noticed earlier in the Sino-Tibetan/Trans-Himalayan languages they investigate—that the negative and interrogative prefixes share the same form. After describing in detail the forms and functions of negative and interrogative prefixes in the Cogtse dialect, this paper argues that in Rgyalrong, the negative and interrogative prefixes are in isomorphism. Such an isomorphic relation between negators and interrogative markers is detected not only in Rgyalrong, but also in other Sino-Tibetan languages, including Chinese. Based on related evidence gleaned from Rgyalrong, the present study proposes possible contexts and mechanisms that ...