Assessment on facile Diels–Alder approach of α-pyrone and terpenoquinone for the expedient synthesis of various natural scaffolds

The development of highly facile synthetic procedures for the expedient synthesis of complex natural molecules is always in demand. As this aspect, the Diels–Alder reaction (DAR) has a versatile approach to the synthesis of complex natural compounds and highly regio-/stereoselcetive heterocyclic scaffolds. Additionally, α-pyrone and terpenoquinone are two versatile key intermediates that are prevalent in various bioactive natural compounds for instance, (±)-crinine, (±)-joubertinamine, (±)-pancratistatin, (−)-cyclozonarone, and 8-ephipuupehedione, etc. Hence, the current review summarizes the Diels–Alder reaction application of α-pyrone and terpenoquinone to the constructive synthesis of various natural products over the past two decades (2001–2021). Equally, it serves as a stencil for the invention and development of new synthetic strategies for high-complex molecular structured natural and heterocyclic molecules. Graphical Abstract: [Figure not available: see fulltext.] © 2022, The Author(s).Russian Science Foundation, RSF; Council on grants of the President of the Russian Federation: 21-13-00304, HШ-2700.2020.3This work was financially supported by the Grants Council of the President of the Russian Federation (# HШ-2700.2020.3) and Russian Scientific Foundation (Grant # 21-13-00304).Council on grants of the President of the Russian Federation, HШ-2700.2020.3, Zyryanov Grigory V., Российский Фонд Фундаментальных Исследований (РФФИ), Grant # 21-13-00304, Zyryanov Grigory V