Halogenating enzymes have evolved in considerable mechanistic diversity. The apparent need for secondary metabolism coincides with the current need to introduce halogens in synthetic products. The potential of halogenating enzymes and, especially, vanadate-dependent haloperoxidases has been insufficiently exploited for synthetic purposes. In this work, we identified potential halogenase sequences by screening algal, fungal, and protobacterial sequence databases, structural modeling of putative halogenases, and mapping and comparing active sites. In a final step, individual haloperoxidases were expressed and kinetically characterized. A vanadate-dependent haloperoxidase from Rhodoplanes roseus was heterologously expressible by E. coli and co...
Vanadium-dependent haloperoxidases (VHPOs) belong to one of the three classes of haloperoxidases wh...
Vanadium-dependent bromoperoxidase (VBPO) carries out the two-electron oxidation of halides using hy...
Flavin-dependent halogenases catalyse halogenation of aromatic compounds. In most cases, this reacti...
Vanadium-dependent haloperoxidases in seaweeds, cyanobacteria, fungi, and possibly phytoplankton pla...
Vanadium-dependent haloperoxidases in seaweeds, cyanobacteria, fungi, and possibly phytoplankton pla...
Some marine and terrestrial organisms produce halogenated compounds which exhibit antibiotic activit...
International audienceVanadium haloperoxidases (VHPO) are key enzymes that oxidize halides and are i...
Les vanadium halopéroxydases (vHPO) sont des enzymes catalysant des halogénations non spécifiques vi...
Vanadium haloperoxidases contain the bare metal oxide vanadate as a prosthetic group and differ stro...
International audienceThe initiation of this study relies on a targeted genome-mining approach to hi...
Vanadium haloperoxidases (V-HPOs) are key enzymes that catalyze halides in the presence of hydrogen ...
Haloperoxidases are a group of enzymes with the ability to catalyse the halogenation of organic comp...
International audienceIn the environment, vanadium-dependent haloperoxidases (VHPO) are likely to pl...
The chemical diversity of natural products is established by an elegant network of biosynthetic mach...
The widespread occurrence of bromine- and chlorine-containing marine natural products has prompted i...
Vanadium-dependent haloperoxidases (VHPOs) belong to one of the three classes of haloperoxidases wh...
Vanadium-dependent bromoperoxidase (VBPO) carries out the two-electron oxidation of halides using hy...
Flavin-dependent halogenases catalyse halogenation of aromatic compounds. In most cases, this reacti...
Vanadium-dependent haloperoxidases in seaweeds, cyanobacteria, fungi, and possibly phytoplankton pla...
Vanadium-dependent haloperoxidases in seaweeds, cyanobacteria, fungi, and possibly phytoplankton pla...
Some marine and terrestrial organisms produce halogenated compounds which exhibit antibiotic activit...
International audienceVanadium haloperoxidases (VHPO) are key enzymes that oxidize halides and are i...
Les vanadium halopéroxydases (vHPO) sont des enzymes catalysant des halogénations non spécifiques vi...
Vanadium haloperoxidases contain the bare metal oxide vanadate as a prosthetic group and differ stro...
International audienceThe initiation of this study relies on a targeted genome-mining approach to hi...
Vanadium haloperoxidases (V-HPOs) are key enzymes that catalyze halides in the presence of hydrogen ...
Haloperoxidases are a group of enzymes with the ability to catalyse the halogenation of organic comp...
International audienceIn the environment, vanadium-dependent haloperoxidases (VHPO) are likely to pl...
The chemical diversity of natural products is established by an elegant network of biosynthetic mach...
The widespread occurrence of bromine- and chlorine-containing marine natural products has prompted i...
Vanadium-dependent haloperoxidases (VHPOs) belong to one of the three classes of haloperoxidases wh...
Vanadium-dependent bromoperoxidase (VBPO) carries out the two-electron oxidation of halides using hy...
Flavin-dependent halogenases catalyse halogenation of aromatic compounds. In most cases, this reacti...