One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD)
- Cunningham, Steve
- Graham, Catriona
- MacLean, Morag
- Aurora, Paul
- Ashworth, Michael
- Barbato, Angelo
- Calder, Alistair
- Carlens, Julia
- Clement, Annick
- Hengst, Meike
- Kammer, Birgit
- Kiper, Nural
- Krenke, Katarzyna
- Kronfeld, Kai
- Lange, Joanna
- Ley-Zaporozhan, Julia
- Nicholson, Andrew G.
- Reu, Simone
- Wesselak, Traudl
- Wetzke, Martin
- Bush, Andrew
- Schwerk, Nicolaus
- Griese, Matthias
Publication date
January 2020
DOI Publisher
Ludwig-Maximilians-Universität München Language
EnglishAbstract
We performed a prospective, observational, cohort study of children newly diagnosed with children's interstitial lung disease (ChILD), with structured follow-up at 4, 8, 12 weeks and 6 and 12 months. 127 children, median age 0.9 (IQR 0.3-7.9) years had dyspnoea (68%, 69/102), tachypnoea (75%, 77/103) and low oxygen saturation (SpO(2)) median 92% (IQR 88-96). Death (n=20, 16%) was the most common in those <6 months of age with SpO(2)<94% and developmental/surfactant disorders. We report for the first time that ChILD survivors improved multiple clinical parameters within 8-12 weeks of diagnosis. These data can inform family discussions and support clinical trial measurements
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