Titration of C-5 Sterol Desaturase Activity Reveals Its Relationship to Candida albicans Virulence and Antifungal Susceptibility Is Dependent upon Host Immune Status
- Regan, Jessica
- DeJarnette, Christian
- Luna-Tapia, Arturo
- Parker, Josie E.
- Reitler, Parker
- Barnett, Stacey
- Tucker, Katie M.
- Kelly, Steven L
- Palmer, Glen E
DOIAbstract
Mutations that completely inactivate Erg3p enable the prevalent human pathogen C. albicans to endure the azole antifungals in vitro . However, such null mutants are less frequently identified in azole-resistant clinical isolates than other resistance mechanisms, and previous studies have reported conflicting outcomes regarding antifungal resistance of these mutants in animal models of infection
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