Add to ORKGCerebral energy deficiency is increasingly recognised as an important feature of multiple sclerosis (MS). Until now, we have lacked non-invasive imaging methods to quantify energy utilisation and mitochondrial function in the human brain. Here, we used novel dual-calibrated functional magnetic resonance imaging (dc-fMRI) to map grey-matter (GM) deoxy-haemoglobin sensitive cerebral blood volume (CBVdHb), cerebral blood flow (CBF), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen consumption (CMRO2) in patients with MS (PwMS) and age/sex matched controls. By integrating a flow-diffusion model of oxygen transport, we evaluated the effective oxygen diffusivity of the capillary network (DC) and the partial pressure of oxyg...
A multiple sclerosis (MS) diagnosis often relies upon clinical presentation and qualitative analysis...
Dual-calibrated fMRI is a multi-parametric technique that allows for the quantification of the resti...
To produce energy and maintain healthy function the brain requires a steady supply of oxygen which i...
Cerebral energy deficiency is increasingly recognised as an important feature of multiple sclerosis ...
Evidence suggests that cerebrovascular function and oxygen consumption are altered in multiple scler...
The brain requires a constant supply of glucose and oxygen to meet metabolic needs at rest and duri...
Background: Cerebral blood flow (CBF) is reduced in normal-appearing white matter (NAWM) of subjects...
The human brain predominantly relies on oxidative metabolism of glucose to meet its enormous energy ...
flow (rCBF), and blood volume (rCBV) have been determined for fifteen patients with multiple scleros...
The human brain predominantly relies on oxidative metabolism of glucose to meet its enormous energy ...
The process of neurovascular coupling ensures that increases in neuronal activity are fed by increas...
Quantitative estimates of cerebral metabolic rate of oxygen utilization using magnetic resonance ima...
The human brain predominantly relies on oxidative metabolism of glucose to meet its enormous energy ...
A multiple sclerosis (MS) diagnosis often relies upon clinical presentation and qualitative analysis...
Dual-calibrated fMRI is a multi-parametric technique that allows for the quantification of the resti...
To produce energy and maintain healthy function the brain requires a steady supply of oxygen which i...
Cerebral energy deficiency is increasingly recognised as an important feature of multiple sclerosis ...
Evidence suggests that cerebrovascular function and oxygen consumption are altered in multiple scler...
The brain requires a constant supply of glucose and oxygen to meet metabolic needs at rest and duri...
Background: Cerebral blood flow (CBF) is reduced in normal-appearing white matter (NAWM) of subjects...
The human brain predominantly relies on oxidative metabolism of glucose to meet its enormous energy ...
flow (rCBF), and blood volume (rCBV) have been determined for fifteen patients with multiple scleros...
The human brain predominantly relies on oxidative metabolism of glucose to meet its enormous energy ...
The process of neurovascular coupling ensures that increases in neuronal activity are fed by increas...
Quantitative estimates of cerebral metabolic rate of oxygen utilization using magnetic resonance ima...
The human brain predominantly relies on oxidative metabolism of glucose to meet its enormous energy ...
A multiple sclerosis (MS) diagnosis often relies upon clinical presentation and qualitative analysis...
Dual-calibrated fMRI is a multi-parametric technique that allows for the quantification of the resti...
To produce energy and maintain healthy function the brain requires a steady supply of oxygen which i...