Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism
- URBANET R
- PILON C
- CALCAGNO A
- PESCHECHERA A
- HUBERT EL
- GIACCHETTI G
- GOMEZ SANCHEZ C
- MULATERO P
- TOFFANIN M
- SONINO N
- ZENNARO MC
- VETTOR R
- FALLO F.
- GIORGINO, Francesco
Publication date
January 2010
DOI Publisher
The Endocrine Society ISSN
0021-972X Citation count (estimate)
24Abstract
OBJECTIVE: The objective of the study was to assess the effect of high aldosterone levels on insulin sensitivity of adipose tissue in humans. METHODS: Visceral adipose tissue (VAT) was obtained from patients with aldosterone-producing adenoma (APA; n=14) and, as controls, nonfunctioning adenoma (NFA; n=14) undergoing laparoscopic adrenalectomy. Homeostasis model assessment index was higher and potassium was lower in APA than NFA (P<0.05). Immunohistochemistry, Western blotting, and real-time PCR were used to detect and quantify mineralocorticoid receptor (MR) expression. Transcript levels of peroxisome proliferative-activated receptor-gamma, insulin receptor, glucose transporter 4, insulin receptor substrate-1 and -2, leptin, adipone...
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