Sinonazalni tumori: paragangliom, polipi nosa, mukokela frontalnog sinusa; dijagnoza, terapija, prognoza – prikaz slučaja

Paragangliomas are rare tumors that for a long time grow without symptoms and originate from neuroendocrinecells of the autonomous nervous system. They are extremely rare both in the nasal cavity and in the sinuses, and there have been only 28 cases described so far. We have shown clinical manifestation, therapy and histopathological analysis in a female patient, whose main symptoms such as the obstruction and the swelling at the base of the nose were caused by polyps and a frontal sinus cyst, while the third tumor was found intrasurgically. The immunohistochemical tests (NSE, NF, S100, CK, EMA, chromogranine, GF) confirmed that the third tumor was the paraganglioma. We have not found any description of paraganglioma associated with nasal polyps and frontal sinus cyst in literature reports published anywhere the world. In the case study, the authors have confirmed, apart from the possibility of endoscopic sinus surgery for paraganglioma, the value of endoscopically controlled biopsy in the patient\u27s regular observation.Paragangliomi su rijetki tumori koji dugo rastu bez simptoma, a potječu od neuroendokrinih stanica autonomnog živčanog sustava. U nosu i u sinusima iznimno su rijetki i do danas je opisano samo 28 slučajeva. Prikazali smo kliničku sliku, način liječenja i histopatološku analizu u bolesnice čiji su glavni simptomi, opstrukcija i oteklina u predjelu nosa prouzročeni polipima i cistom frontalnog sinusa, a intraoperacijski je na|en i treći tumor za koji su imunohistokemijske pretrage (NSE, NF, S100, CK, EMA, kromogranih, GF) potvrdile da je paragangliom. Udruženost paraganglioma s polipima nosa i cistom frontalnog sinusa nismo našli opisanu u svjetskoj literaturi. Autori su u radu, osim mogućnosti endoskopske sinusne kirurgije, u liječenju paraganglioma potvrdili vrijednost endoskopski kontroliranih biopsija pri redovitom praćenju bolesnika