Symptom association for gastroesophageal reflux disease by PH monitoring after peroral endoscopic myotomy: GERD and symptoms after POEM

Introduction: There are limited data correlating symptoms with reflux episodes during pH studies after POEM. Methods: Consecutive patients who underwent POEM followed ≥6 months later by 48-hour ambulatory wireless pH testing off antisecretory therapy were identified. Reflux symptom association (RSA) was defined as SAP >95%. Results: The most frequent of symptoms of heartburn (47.2%), cough (45.1%) and chest pain (39.6%) were associated with a positive RSA (SAP >95%) in 20.9%, 17.1% and 19.4%, respectively. Discussion: There is poor correlation between reported symptoms and esophageal acid exposure during pH testing after POEM