The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy
- Sancey, Lucie
- Lux, François
- Kotb, Shady
- Roux, Stéphane
- Dufort, Sandrine
- Bianchi, Andrea
- Cremillieux, Yannick
- Fries, Peter
- Coll, Jean-Luc
- Rodriguez-Lafrasse, Claire
- Janier, Marc
- Dutreix, Marie
- Barberi-Heyob, Muriel
- Boschetti, Frédéric
- Denat, Franck
- Louis, Cédric
- Porcel, Erika
- Lacombe, Sandrine
- Le Duc, Géraldine
- Deutsch, Eric
- Perfettini, Jean-Luc
- Detappe, Alexandre
- Verry, Camille
- Berbeco, Ross
- Butterworth, Karl
- Mcmahon, Stephen
- Prise, Kevin
- Perriat, Pascal
- Tillement, Olivier
DOIAbstract
International audienceA new efficient type of gadolinium-based theranostic agent (AGuIX) has recently been developed for magnetic resonance imaging (MRI)-guided radiotherapy. These new particles consist of a polysiloxane network surrounded by a number of gadolinium chelates, usually 10. Due to their small size (<5 nm), AGuIX typically exhibit biodistributions that are almost ideal for diagnostic and therapeutic purposes. For example, while a significant proportion of these particles accumulate in tumours, the remainder is rapidly eliminated by the renal route. In addition, these particles present no evidence of toxicity, in the absence of irradiation with up to 10 times the planned dose for clinical trials. AGuIX particles have been proven ...
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