Design, synthesis and biological evaluation of new thalidomide analogues as TNF-alpha and IL-6 production inhibitors
- Chaulet, Charlotte
- Croix, Cecile
- Alagille, David
- Normand, Sylvain
- Delwail, Adriana
- Favot, Laure
- Lecron, Jean-Claude
- Viaud-Massuard, Marie-Claude
DOIAbstract
International audienceSeveral thalidomide analogues were synthesized and compared to thalidomide and its more active analogue, lenalidomide, for their ability to inhibit the production of the pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 by LPS-activated peripheral blood mononuclear cells (PBMCs). Among these compounds, two analogues containing sulfonyl group displayed interesting downregulation of TNF-alpha and IL-6 production. (C) 2010 Elsevier Ltd. All rights reserved
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