A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents. These hybrids exhibited relatively high cytotoxic activity against cancer cell line HepG2 (IC50 = 2.86–36.34 μM), while normal cell line LO2 was less sensitive to these hybrids (IC50 = 36.37–248.39 μM). On the whole, among all the compounds tested, compound 4e, with a mean IC50 value of 2.86 μM, was the most active. The novel hybrids may find their pharmaceutical applications after further investigations
The synthesis and cytotoxic evaluation of 3-(alkyl)(alkyl-substituted) spiro[(dihydroimidazo-2,4-dio...
Several novel spiro derivatives of parthenin (1) have been synthesized by the dipolar cycloaddition ...
Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with limited treatment option...
A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a]pyrimidine hybrids were designed, s...
Owing to the downsides of existing anticancer drugs, it is necessary to find more effective and sele...
In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffol...
The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed tha...
A highly stereoselective, one-pot, multicomponent method has been developed to synthesize pyrrolizid...
In search of novel and effective antitumor agents, pyrazoline-substituted pyrrolidine-2,5-dione hybr...
A series of spirooxindolopyrrolidine fused N-styrylpiperidone heterocyclic hybrids has been synthesi...
Two series of quinolinquinone derivatives, 2′H-spiro[imidazolidine-4,3′-thieno[2,3-g]quinoline]-2,4′...
A new series of spirooxindoles based on ethylene derivatives having furan aryl moiety are reported. ...
Two series of quinolinquinone derivatives, 2′H-spiro[imidazolidine-4,3′-thieno[2,3-g]quinoline]-2,4′...
Anticancer screening of several novel thienopyrimidines has been performed. The thienopyrimidine der...
New anticancer agents are highly needed to overcome cancer cell resistance. A novel series of pyrimi...
The synthesis and cytotoxic evaluation of 3-(alkyl)(alkyl-substituted) spiro[(dihydroimidazo-2,4-dio...
Several novel spiro derivatives of parthenin (1) have been synthesized by the dipolar cycloaddition ...
Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with limited treatment option...
A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a]pyrimidine hybrids were designed, s...
Owing to the downsides of existing anticancer drugs, it is necessary to find more effective and sele...
In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffol...
The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed tha...
A highly stereoselective, one-pot, multicomponent method has been developed to synthesize pyrrolizid...
In search of novel and effective antitumor agents, pyrazoline-substituted pyrrolidine-2,5-dione hybr...
A series of spirooxindolopyrrolidine fused N-styrylpiperidone heterocyclic hybrids has been synthesi...
Two series of quinolinquinone derivatives, 2′H-spiro[imidazolidine-4,3′-thieno[2,3-g]quinoline]-2,4′...
A new series of spirooxindoles based on ethylene derivatives having furan aryl moiety are reported. ...
Two series of quinolinquinone derivatives, 2′H-spiro[imidazolidine-4,3′-thieno[2,3-g]quinoline]-2,4′...
Anticancer screening of several novel thienopyrimidines has been performed. The thienopyrimidine der...
New anticancer agents are highly needed to overcome cancer cell resistance. A novel series of pyrimi...
The synthesis and cytotoxic evaluation of 3-(alkyl)(alkyl-substituted) spiro[(dihydroimidazo-2,4-dio...
Several novel spiro derivatives of parthenin (1) have been synthesized by the dipolar cycloaddition ...
Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with limited treatment option...