Currently, RNAi based approaches for cancer treatment involving short double stranded RNA molecules (siRNA) are under vigorous scrutinization. Due to numerous biological obstacles, siRNA delivery into target cells requires protective escort. On the other hand, combining of siRNA-mediated gene silencing and action of conventional chemotherapeutics can propose additional enhancement of anticancer activity. In the present study, we investigated a siRNA cocktail able to downregulate anti-apoptotic genes (BCL-xL, BCL-2, MCL-1) and the chemotherapeutic agent 5-fluorouracil (5-FU) to evaluate multi-target cytotoxic effect on human cervical carcinoma cells (HeLa cell line). Novel phosphorus containing dendrimers of 3rd and 4th generations (namely A...
Despite great progress in recent years, efficient delivery of gene therapy or chemotherapy drugs int...
Discovering chemosensitivity pathways or nodes is an attractive strategy for formulating new drug co...
Chemotherapeutics drugs play a pivotal role in the treatment of cancer. However, many issues generat...
International audienceCurrently, RNAi based approaches for cancer treatment involving short double s...
International audienceThis paper examines a perspective to use newly engineered nanomaterials as eff...
The recently discovered small interfering RNA (siRNA) holds great promise in cancer therapy. However...
International audienceSmall interfering RNA (siRNA) is emerging as a novel therapeutic for treating ...
Although small interfering RNA (siRNA) treatment holds great promise for the treatment of cancers, t...
Small interfering RNA (siRNA) is emerging as a novel therapeutic for treating various diseases, prov...
International audienceMetastasis is the cause of most (>90%) cancer deaths and currently lacks effec...
RNA Interference (RNAi) has brought revolutionary transformations in cancer management in the past t...
RNA Interference (RNAi) has brought revolutionary transformations in cancer management in the past t...
The efficiency of siRNA is limited by its low resistance against enzymatic degradation, limited perm...
Small interfering RNA (siRNA) is emerging as novel therapeutics for treating various diseases, provi...
Although chemotherapy is a first option in treatment of cancer patients, drug resistance has led to ...
Despite great progress in recent years, efficient delivery of gene therapy or chemotherapy drugs int...
Discovering chemosensitivity pathways or nodes is an attractive strategy for formulating new drug co...
Chemotherapeutics drugs play a pivotal role in the treatment of cancer. However, many issues generat...
International audienceCurrently, RNAi based approaches for cancer treatment involving short double s...
International audienceThis paper examines a perspective to use newly engineered nanomaterials as eff...
The recently discovered small interfering RNA (siRNA) holds great promise in cancer therapy. However...
International audienceSmall interfering RNA (siRNA) is emerging as a novel therapeutic for treating ...
Although small interfering RNA (siRNA) treatment holds great promise for the treatment of cancers, t...
Small interfering RNA (siRNA) is emerging as a novel therapeutic for treating various diseases, prov...
International audienceMetastasis is the cause of most (>90%) cancer deaths and currently lacks effec...
RNA Interference (RNAi) has brought revolutionary transformations in cancer management in the past t...
RNA Interference (RNAi) has brought revolutionary transformations in cancer management in the past t...
The efficiency of siRNA is limited by its low resistance against enzymatic degradation, limited perm...
Small interfering RNA (siRNA) is emerging as novel therapeutics for treating various diseases, provi...
Although chemotherapy is a first option in treatment of cancer patients, drug resistance has led to ...
Despite great progress in recent years, efficient delivery of gene therapy or chemotherapy drugs int...
Discovering chemosensitivity pathways or nodes is an attractive strategy for formulating new drug co...
Chemotherapeutics drugs play a pivotal role in the treatment of cancer. However, many issues generat...