The proneural factor Achaete-scute complex-like 1 (Ascl1/Mash1) acts as a pioneering transcription factor that initializes neuronal reprogramming. It drives neural progenitors and non-neuronal cells to exit the cell cycle, and promotes neuronal differentiation by activating neuronal target genes, even those that are normally repressed. Importantly, force-expression of Ascl1 was shown to drive proliferative reactive astroglia formed during stroke and glioblastoma stem cells towards neuronal differentiation, and this could potentially diminish CNS damage resulting from their proliferation. As a pro-neural factor, Ascl1 also has the general effect of enhancing neurite growth by damaged or surviving neurons. Here, a hypothesis that brain pathol...
The proneural transcription factor Ascl1 coordinates gene expression in both proliferating and diffe...
SummaryDirect conversion of nonneural cells to functional neurons holds great promise for neurologic...
Neuroblastoma is believed to arise from sympathetic neuroblast precursors that fail to engage the ne...
Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal differentiation when...
The proneural transcription factor Achaete-scute complex-like 1 (Ascl1) is a major regulator of neur...
The proneural transcription factor Achaete-scute complex-like 1 (Ascl1) is a major regulator of neur...
Tumours represent aberrant organogenesis with growth caused by unlimited proliferation and failure o...
The proneural transcription factor Achaete-scute complex-like 1 (Ascl1) is a major regulator of neur...
Proneural transcription factors (TFs) such as Ascl1 function as master regulators of neurogenesis in...
The Sonic Hedgehog (Shh) signaling pathway is important for neurogenesis in vivo. Gli transcription ...
The Sonic Hedgehog (Shh) signaling pathway is important for neurogenesis in vivo. Gli transcription ...
Neurogenesis is a cell differentiation program in which neural stem cells undergo extensive and pre...
SummaryThe proneural transcription factor Ascl1 coordinates gene expression in both proliferating an...
The Sonic Hedgehog (Shh) signaling pathway is important for neurogenesis in vivo. Gli transcription ...
The proneural transcription factor Ascl1 coordinates gene expression in both proliferating and diffe...
The proneural transcription factor Ascl1 coordinates gene expression in both proliferating and diffe...
SummaryDirect conversion of nonneural cells to functional neurons holds great promise for neurologic...
Neuroblastoma is believed to arise from sympathetic neuroblast precursors that fail to engage the ne...
Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal differentiation when...
The proneural transcription factor Achaete-scute complex-like 1 (Ascl1) is a major regulator of neur...
The proneural transcription factor Achaete-scute complex-like 1 (Ascl1) is a major regulator of neur...
Tumours represent aberrant organogenesis with growth caused by unlimited proliferation and failure o...
The proneural transcription factor Achaete-scute complex-like 1 (Ascl1) is a major regulator of neur...
Proneural transcription factors (TFs) such as Ascl1 function as master regulators of neurogenesis in...
The Sonic Hedgehog (Shh) signaling pathway is important for neurogenesis in vivo. Gli transcription ...
The Sonic Hedgehog (Shh) signaling pathway is important for neurogenesis in vivo. Gli transcription ...
Neurogenesis is a cell differentiation program in which neural stem cells undergo extensive and pre...
SummaryThe proneural transcription factor Ascl1 coordinates gene expression in both proliferating an...
The Sonic Hedgehog (Shh) signaling pathway is important for neurogenesis in vivo. Gli transcription ...
The proneural transcription factor Ascl1 coordinates gene expression in both proliferating and diffe...
The proneural transcription factor Ascl1 coordinates gene expression in both proliferating and diffe...
SummaryDirect conversion of nonneural cells to functional neurons holds great promise for neurologic...
Neuroblastoma is believed to arise from sympathetic neuroblast precursors that fail to engage the ne...