Numerous conflicting criteria exist in building design optimization, such as energy consumption, greenhouse gas emission and indoor thermal performance. Different simulation-based optimization strategies and various optimization algorithms have been developed. A few of them are analyzed and compared in solving building design problems. This paper presents an efficient optimization framework to facilitate optimization designs with the aid of commercial simulation software and MATLAB. The performances of three optimization strategies, including the proposed approach, GenOpt method and artificial neural network (ANN) method, are investigated using a case study of a simple building energy model. Results show that the proposed optimization frame...