Neuroblastoma (NB) is the most common extracranial solid tumor of childhood and is a rapidly growing, highly-vascularized cancer. NBs frequently express angiogenic factors and high tumor angiogenesis has been associated with poor outcomes. Placental growth factor (PlGF) is an angiogenic protein belonging to the vascular endothelial growth factor (VEGF) family and is up-regulated mainly in pathologic conditions. Recently, PlGF was identified as a member of a gene expression signature characterizing highly malignant NB stem cells drawing attention as a potential therapeutic target in NB. In the present study, we sought to investigate the expression of PlGF in NB patients and the effect of PlGF inhibition on high-risk MYCN-non-amplified SK-N-A...
Vascular endothelial growth factor (VEGF) stimulates angiogenesis by activating VEGF receptor-2 (VEG...
SummaryIt has been recently reported that treatment with an anti-placenta growth factor (PlGF) antib...
The role of Placenta growth factor (PlGF) in physiological angiogenesis is quiescent, preclinical an...
Neuroblastoma (NB) is the most common extracranial solid tumor of childhood and is a rapidly growing...
Members of the vascular endothelial growth factor (VEGF) family are critical players in angiogenesis...
Angiogenesis is one of the crucial events for cancer development and growth. Two members of the vasc...
It has previously been suggested that in human brain tumours, endothelial cell proliferation during ...
The growth and vascularization of prostate cancer is dependent on interactions between cancer cells ...
AbstractTumor growth and metastasis require concomitant growth of new blood vessels, which are stimu...
Placenta growth factor (PlGF) is a key regulator of pathological angiogenesis and its overexpression...
Many proliferative diseases, most typically cancer, are driven by uncontrolled blood vessel growth. ...
SummaryNovel antiangiogenic strategies with complementary mechanisms are needed to maximize efficacy...
Placental growth factor (PLGF) belongs to the VEGF family, which among the three VEGF receptors bind...
Inhibition of Dll4 (delta-like ligand 4)-Notch signaling-mediated tumor angiogenesis is an attractiv...
Vascular endothelial growth factor (VEGF) stimulates angiogenesis by activating VEGF receptor-2 (VEG...
SummaryIt has been recently reported that treatment with an anti-placenta growth factor (PlGF) antib...
The role of Placenta growth factor (PlGF) in physiological angiogenesis is quiescent, preclinical an...
Neuroblastoma (NB) is the most common extracranial solid tumor of childhood and is a rapidly growing...
Members of the vascular endothelial growth factor (VEGF) family are critical players in angiogenesis...
Angiogenesis is one of the crucial events for cancer development and growth. Two members of the vasc...
It has previously been suggested that in human brain tumours, endothelial cell proliferation during ...
The growth and vascularization of prostate cancer is dependent on interactions between cancer cells ...
AbstractTumor growth and metastasis require concomitant growth of new blood vessels, which are stimu...
Placenta growth factor (PlGF) is a key regulator of pathological angiogenesis and its overexpression...
Many proliferative diseases, most typically cancer, are driven by uncontrolled blood vessel growth. ...
SummaryNovel antiangiogenic strategies with complementary mechanisms are needed to maximize efficacy...
Placental growth factor (PLGF) belongs to the VEGF family, which among the three VEGF receptors bind...
Inhibition of Dll4 (delta-like ligand 4)-Notch signaling-mediated tumor angiogenesis is an attractiv...
Vascular endothelial growth factor (VEGF) stimulates angiogenesis by activating VEGF receptor-2 (VEG...
SummaryIt has been recently reported that treatment with an anti-placenta growth factor (PlGF) antib...
The role of Placenta growth factor (PlGF) in physiological angiogenesis is quiescent, preclinical an...