The Hepadnaviridae family of small, enveloped DNA viruses are characterized by a strict host range and hepatocyte tropism. The prototype hepatitis B virus (HBV) is a major human pathogen and constitutes a public health problem, especially in high-incidence areas. Reporter-expressing recombinant viruses are powerful tools in both studies of basic virology and development of antiviral therapeutics. In addition, the highly restricted tropism of HBV for human hepatocytes makes it an ideal tool for hepatocyte-targeting in vivo applications such as liver-specific gene delivery. However, compact genome organization and complex replication mechanisms of hepadnaviruses have made it difficult to engineer replication-competent recombinant viruses that...
The construction of the first stable human cell lines that express and secrete authentic hepatitis B...
[[abstract]]Baculovirus has been employed for a wide variety of applications. In this study, we furt...
Background: Hepatitis B virus (HBV) is among the smallest DNA viruses resulting in ~800,000 deaths e...
The Hepadnaviridae family of small, enveloped DNA viruses are characterized by a strict host range a...
Hepatitis B virus (HBV) takes humans as its sole natural host, and productive infection in vivo is r...
grantor: University of TorontoThe hepatitis B virus remains a prevalent global problem des...
<div><p>Viral vectors are engineered virus variants able to deliver nonviral genetic information int...
Viral vectors are engineered virus variants able to deliver nonviral genetic information into cells,...
International audienceChronic hepatitis B virus (HBV) infection is characterized by functionally imp...
The hepatitis B virus (HBV) infection is a public health problem worldwide, particularly in East Asi...
Hepatitis B virus (HBV) is hyperendemic to southern Africa and parts of Asia where it is a major ca...
As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to viral...
Hepatitis B virus (HBV) infects liver cells resulting in hepatitis B infection. In approximately 90%...
International audienceDNA recombinant technology has radically changed hepatitis B virus (HBV) virol...
Despite the availability of an effective vaccine against hepatitis B virus (HBV), chronic infection ...
The construction of the first stable human cell lines that express and secrete authentic hepatitis B...
[[abstract]]Baculovirus has been employed for a wide variety of applications. In this study, we furt...
Background: Hepatitis B virus (HBV) is among the smallest DNA viruses resulting in ~800,000 deaths e...
The Hepadnaviridae family of small, enveloped DNA viruses are characterized by a strict host range a...
Hepatitis B virus (HBV) takes humans as its sole natural host, and productive infection in vivo is r...
grantor: University of TorontoThe hepatitis B virus remains a prevalent global problem des...
<div><p>Viral vectors are engineered virus variants able to deliver nonviral genetic information int...
Viral vectors are engineered virus variants able to deliver nonviral genetic information into cells,...
International audienceChronic hepatitis B virus (HBV) infection is characterized by functionally imp...
The hepatitis B virus (HBV) infection is a public health problem worldwide, particularly in East Asi...
Hepatitis B virus (HBV) is hyperendemic to southern Africa and parts of Asia where it is a major ca...
As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to viral...
Hepatitis B virus (HBV) infects liver cells resulting in hepatitis B infection. In approximately 90%...
International audienceDNA recombinant technology has radically changed hepatitis B virus (HBV) virol...
Despite the availability of an effective vaccine against hepatitis B virus (HBV), chronic infection ...
The construction of the first stable human cell lines that express and secrete authentic hepatitis B...
[[abstract]]Baculovirus has been employed for a wide variety of applications. In this study, we furt...
Background: Hepatitis B virus (HBV) is among the smallest DNA viruses resulting in ~800,000 deaths e...