Despite intense research, few treatments are available for most neurological disorders. Demyelinating diseases are no exception. This is perhaps not surprising considering the multifactorial nature of these diseases, which involve complex interactions between immune system cells, glia and neurons. In the case of multiple sclerosis, for example, there is no unanimity among researchers about the cause or even which system or cell type could be ground zero. This situation precludes the development and strategic application of mechanism-based therapies. We will discuss how computational modeling applied to questions at different biological levels can help link together disparate observations and decipher complex mechanisms whose solutions are n...
Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes...
Healthy functioning is an emergent property of the network of interacting biomolecules that comprise...
Demyelinating diseases of the central nervous system (CNS), such as multiple sclerosis (MS), are cha...
Despite intense research, few treatments are available for most neurological disorders. Demyelinatin...
Abstract: Despite intense research, few treatments are available for most neurological disorders. De...
The investigation of synaptic functions remains one of the most fascinating challenges in the field...
Multiple Sclerosis (MS) is a chronic and potentially highly disabling disease that can cause permane...
Movement disorders arise from the complex interplay of multiple changes to neural circuits. Successf...
As of today, 20 disease-modifying drugs (DMDs) have been approved for the treatment of relapsing mul...
This book focuses on our current understanding of brain dynamics in various brain disorders and how ...
Computational models have become an integral part of basic neuroscience and have facilitated some of...
Neurodegenerative disease is an umbrella term for pathologies that primarily damage neurons. As thei...
Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes...
In this paper we derive a reaction-diffusion-chemotaxis model for the dynamics of multiple sclerosis...
This project presents a mathematical model of the biochemical pathways involved in remyelination dur...
Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes...
Healthy functioning is an emergent property of the network of interacting biomolecules that comprise...
Demyelinating diseases of the central nervous system (CNS), such as multiple sclerosis (MS), are cha...
Despite intense research, few treatments are available for most neurological disorders. Demyelinatin...
Abstract: Despite intense research, few treatments are available for most neurological disorders. De...
The investigation of synaptic functions remains one of the most fascinating challenges in the field...
Multiple Sclerosis (MS) is a chronic and potentially highly disabling disease that can cause permane...
Movement disorders arise from the complex interplay of multiple changes to neural circuits. Successf...
As of today, 20 disease-modifying drugs (DMDs) have been approved for the treatment of relapsing mul...
This book focuses on our current understanding of brain dynamics in various brain disorders and how ...
Computational models have become an integral part of basic neuroscience and have facilitated some of...
Neurodegenerative disease is an umbrella term for pathologies that primarily damage neurons. As thei...
Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes...
In this paper we derive a reaction-diffusion-chemotaxis model for the dynamics of multiple sclerosis...
This project presents a mathematical model of the biochemical pathways involved in remyelination dur...
Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes...
Healthy functioning is an emergent property of the network of interacting biomolecules that comprise...
Demyelinating diseases of the central nervous system (CNS), such as multiple sclerosis (MS), are cha...