The janus kinases (JAK), extracellular signal-regulated kinases (ERK) and signal transducers and activators of transcription (STAT) pathways have been shown to play a cardioprotective role. We previously gave evidence that melanocortins afford cardioprotection in conditions of myocardial ischemia/reperfusion. Here we aimed to investigate the influence of melanocortins on the JAK/ERK/STAT signaling in cardiac and systemic responses to prolonged myocardial ischemia/reperfusion. Ischemia was produced in rats by ligature of the left anterior descending coronary artery for 30 min. At the end of the 2-h reperfusion, western blot analysis of the cardioprotective transcription factors pJAK2, pERK1/2, pTyr-STAT3 and pSer-STAT3, the inflammatory medi...
The signal transducer and activator of transcription (STAT) proteins are a family of transcription f...
Background - Adiponectin (AD) cardioprotective activities are mediated by AMPK, a fuel-sensing molec...
Cardiovascular pathologies are an enormous burden in human health and despite the vast amount of res...
The janus kinases (JAK), extracellular signal-regulated kinases (ERK) and signal transducers and act...
Melanocortin peptides afford cardioprotection during myocardial ischemia/reperfusion via janus kinas...
Recently we reported that an efferent vagal fibre-mediated cholinergic protective pathway, activated...
We previously reported that melanocortins afford cardioprotection in conditions of experimental myoc...
\u3b1-Melanocyte-stimulating hormone (\u3b1-MSH) is a pro-opiomelanocortin (POMC)-derived peptide th...
In rats subjected to myocardial ischemia/reperfusion, melanocortin peptides, including gamma(1)-mela...
Investigation of the mechanisms activated by endogenous inhibitory pathways can lead to identificati...
Myocardial ischemia/reperfusion induces ventricular tachycardia (VT), ventricular fibrillation (VF) ...
The signal transducer and activator of transcription (STAT) proteins are a family of transcription f...
Myocardial ischemia reperfusion injury (IRI) adversely affects cardiac performance and the prognosis...
The influence of the melanocortin peptide ACTH-(1-24) (adrenocorticotropin) on the consequences of s...
AbstractMelanocortin peptides exert, in rats, a protective effect in myocardial ischaemia followed b...
The signal transducer and activator of transcription (STAT) proteins are a family of transcription f...
Background - Adiponectin (AD) cardioprotective activities are mediated by AMPK, a fuel-sensing molec...
Cardiovascular pathologies are an enormous burden in human health and despite the vast amount of res...
The janus kinases (JAK), extracellular signal-regulated kinases (ERK) and signal transducers and act...
Melanocortin peptides afford cardioprotection during myocardial ischemia/reperfusion via janus kinas...
Recently we reported that an efferent vagal fibre-mediated cholinergic protective pathway, activated...
We previously reported that melanocortins afford cardioprotection in conditions of experimental myoc...
\u3b1-Melanocyte-stimulating hormone (\u3b1-MSH) is a pro-opiomelanocortin (POMC)-derived peptide th...
In rats subjected to myocardial ischemia/reperfusion, melanocortin peptides, including gamma(1)-mela...
Investigation of the mechanisms activated by endogenous inhibitory pathways can lead to identificati...
Myocardial ischemia/reperfusion induces ventricular tachycardia (VT), ventricular fibrillation (VF) ...
The signal transducer and activator of transcription (STAT) proteins are a family of transcription f...
Myocardial ischemia reperfusion injury (IRI) adversely affects cardiac performance and the prognosis...
The influence of the melanocortin peptide ACTH-(1-24) (adrenocorticotropin) on the consequences of s...
AbstractMelanocortin peptides exert, in rats, a protective effect in myocardial ischaemia followed b...
The signal transducer and activator of transcription (STAT) proteins are a family of transcription f...
Background - Adiponectin (AD) cardioprotective activities are mediated by AMPK, a fuel-sensing molec...
Cardiovascular pathologies are an enormous burden in human health and despite the vast amount of res...