The mechanism by which the hippocampus facilitates declarative memory formation appears to involve, among other things, restructuring of the actin cytoskeleton within neuronal dendrites. One protein involved in this process is cortactin, which is an important link between extracellular signaling and cytoskeletal reorganization. In this paper, we demonstrate that total hippocampal cortactin, as well as Y421-phosphorylated cortactin are transiently reduced following spatial working memory formation in the radial arm maze (RAM). Because cortactin is a substrate of the cysteine protease calpain, we also assessed the effect of chronic calpain inhibition on RAM performance and cortactin expression. Calpain inhibition impaired spatial working memo...
Stabilization of long-term potentiation (LTP) depends on multiple signaling cascades linked to actin...
In the adult mammalian brain, new neurons continue to be produced throughout life in two main region...
© 2022, The Author(s).Spatial learning and memory flexibility are known to require long-term potenti...
Postsynaptic structures on excitatory neurons, dendritic spines, are actin-rich. It is well known th...
Postsynaptic structures on excitatory neurons, dendritic spines, are actin-rich. It is well known th...
Abstract Memory consolidation, reconsolidation, and extinction have been shown to share similar mole...
Calpains are calcium-dependent enzymes that determine the fate of proteins through regulated proteol...
Spines may undergo rapid, activity-dependent changes in shape and size, reflecting reorganization of...
Spines may undergo rapid, activity-dependent changes in shape and size, reflecting reorganization of...
Spines may undergo rapid, activity-dependent changes in shape and size, reflecting reorganization of...
2011-07-27Learning and memory are important functions shared by the living world. In humans, these t...
UnrestrictedIn 1984, a hypothesis was proposed that boldly attempted to describe the cellular proces...
Exposure to drug-paired cues causes drug memories to be in a destabilized state and interfering with...
In the adult mammalian brain, new neurons continue to be produced throughout life in two main region...
Stabilization of long-term potentiation (LTP) depends on multiple signaling cascades linked to actin...
Stabilization of long-term potentiation (LTP) depends on multiple signaling cascades linked to actin...
In the adult mammalian brain, new neurons continue to be produced throughout life in two main region...
© 2022, The Author(s).Spatial learning and memory flexibility are known to require long-term potenti...
Postsynaptic structures on excitatory neurons, dendritic spines, are actin-rich. It is well known th...
Postsynaptic structures on excitatory neurons, dendritic spines, are actin-rich. It is well known th...
Abstract Memory consolidation, reconsolidation, and extinction have been shown to share similar mole...
Calpains are calcium-dependent enzymes that determine the fate of proteins through regulated proteol...
Spines may undergo rapid, activity-dependent changes in shape and size, reflecting reorganization of...
Spines may undergo rapid, activity-dependent changes in shape and size, reflecting reorganization of...
Spines may undergo rapid, activity-dependent changes in shape and size, reflecting reorganization of...
2011-07-27Learning and memory are important functions shared by the living world. In humans, these t...
UnrestrictedIn 1984, a hypothesis was proposed that boldly attempted to describe the cellular proces...
Exposure to drug-paired cues causes drug memories to be in a destabilized state and interfering with...
In the adult mammalian brain, new neurons continue to be produced throughout life in two main region...
Stabilization of long-term potentiation (LTP) depends on multiple signaling cascades linked to actin...
Stabilization of long-term potentiation (LTP) depends on multiple signaling cascades linked to actin...
In the adult mammalian brain, new neurons continue to be produced throughout life in two main region...
© 2022, The Author(s).Spatial learning and memory flexibility are known to require long-term potenti...