Clinical Issues in Management of Klinefelter’s Syndrome.

The chapter deals with the clinical issues of Klinefelter Syndrome (KS)according to the review of the literature. In particular the phenotype of KS is discussed according to the time of the diagnosis (prenatal, neonatal, infancy, adolescence, adulthood). The possible comorbidities and their treatment associated to KS and their treatment are reviewed. The role of sex steroids on the phenotype of the disease is largely discussed