Niemann-Pick C (NPC) disease is a fatal neurodegenerative disorder characterized by the accumulation of free cholesterol in lysosomes. We have previously reported that oxidative stress is the main upstream stimulus activating the proapoptotic c-Abl/p73 pathway in NPC neurons. We have also observed accumulation of vitamin E in NPC lysosomes, which could lead to a potential decrease of its bioavailability. Our aim was to determine if dietary vitamin E supplementation could improve NPC disease in mice. NPC mice received an alpha-tocopherol (α-TOH) supplemented diet and neurological symptoms, survival, Purkinje cell loss, α-TOH and nitrotyrosine levels, astrogliosis, and the c-Abl/p73 pathway functions were evaluated. In addition, the effect o...
Alzheimer’s disease (AD) is a neurodegenerative disorder representing the major cause of dementia. I...
<div><p>Niemann-Pick Type C (NPC) disease is an autosomal recessive neurodegenerative disorder cause...
Vitamin C (Vit C) is anutrient present in many foods, particularly citrus fruits, green vegetables, ...
Niemann-Pick C (NPC) disease is a fatal neurodegenerative disorder characterized by the accumulation...
Niemann-Pick C (NPC) disease is a fatal neurodegenerative disorder characterized by the accumulation...
AbstractNiemann–Pick C disease (NPC) is a neuro-visceral lysosomal storage disorder mainly caused by...
Vitamin E family is composed of different tocopherols and tocotrienols that are well-known as antiox...
Niemann-Pick type C (NPC) disease is a neurovisceral atypical lipid storage disorder involving the a...
Effective disease-modifying treatments are an urgent need for Parkinson's disease (PD). A putative s...
Niemann-Pick type C (NPC) is a neurodegenerative disease characterized by the intralysosomal accumul...
Effective disease-modifying treatments are an urgent need for Parkinson's disease (PD). A putative s...
Niemann-Pick Type C (NPC) disease is an autosomal recessive neurodegenerative disorder caused in mos...
<p>(A) immunofluorescent staining of lumbar spinal cords sections prepared from indicated mice showe...
Vitamin E is often associated with health benefits, such as antioxidant, anti-inflammatory and chole...
Vitamin C (Vit C) is anutrient present in many foods, particularly citrus fruits, green vegetables, ...
Alzheimer’s disease (AD) is a neurodegenerative disorder representing the major cause of dementia. I...
<div><p>Niemann-Pick Type C (NPC) disease is an autosomal recessive neurodegenerative disorder cause...
Vitamin C (Vit C) is anutrient present in many foods, particularly citrus fruits, green vegetables, ...
Niemann-Pick C (NPC) disease is a fatal neurodegenerative disorder characterized by the accumulation...
Niemann-Pick C (NPC) disease is a fatal neurodegenerative disorder characterized by the accumulation...
AbstractNiemann–Pick C disease (NPC) is a neuro-visceral lysosomal storage disorder mainly caused by...
Vitamin E family is composed of different tocopherols and tocotrienols that are well-known as antiox...
Niemann-Pick type C (NPC) disease is a neurovisceral atypical lipid storage disorder involving the a...
Effective disease-modifying treatments are an urgent need for Parkinson's disease (PD). A putative s...
Niemann-Pick type C (NPC) is a neurodegenerative disease characterized by the intralysosomal accumul...
Effective disease-modifying treatments are an urgent need for Parkinson's disease (PD). A putative s...
Niemann-Pick Type C (NPC) disease is an autosomal recessive neurodegenerative disorder caused in mos...
<p>(A) immunofluorescent staining of lumbar spinal cords sections prepared from indicated mice showe...
Vitamin E is often associated with health benefits, such as antioxidant, anti-inflammatory and chole...
Vitamin C (Vit C) is anutrient present in many foods, particularly citrus fruits, green vegetables, ...
Alzheimer’s disease (AD) is a neurodegenerative disorder representing the major cause of dementia. I...
<div><p>Niemann-Pick Type C (NPC) disease is an autosomal recessive neurodegenerative disorder cause...
Vitamin C (Vit C) is anutrient present in many foods, particularly citrus fruits, green vegetables, ...