The overexpression of gastrin-releasing peptide receptor (GRPR) in cancer can be used for peptide-receptor mediated radionuclide imaging and therapy. We have previously shown that an antagonist analog of bombesin RM26 conjugated to 1,4,7-triazacyclononane-N,N\u27,N\u27\u27-triacetic acid (NOTA) via a diethyleneglycol (PEG2) spacer (NOTA-PEG2-RM26) and labeled with 68Ga can be used for imaging of GRPR-expressing tumors. In this study, we evaluated if a variation of mini-PEG spacer length can be used for optimization of targeting properties of the NOTA-conjugated RM26. A series of analogs with different PEG-length (n = 2, 3, 4, 6) was synthesized, radiolabeled and evaluated in vitro and in vivo. The IC50 values of natGa-NOTA-PEGn-RM26 (n = ...
Item does not contain fulltextThe gastrin-releasing peptide receptor (GRPR) is overexpressed in huma...
Gastrin-releasing peptide receptors (GRPrs) are overexpressed on a variety of human cancers, providi...
Gastrin-releasing peptide receptors (GRPrs) are overexpressed on a variety of human cancers, providi...
The overexpression of gastrin-releasing peptide receptor (GRPR) in cancer can be used for peptide-re...
The overexpression of gastrin-releasing peptide receptor (GRPR) in cancer can be used for peptide-re...
The overexpression of gastrin-releasing peptide receptor (GRPR) in cancer can be used for peptide-re...
INTRODUCTION The gastrin-releasing peptide receptor (GRPR) was shown to be expressed with high de...
Expression of the gastrin-releasing peptide receptor (GRPR) in prostate cancer suggests that this re...
Expression of the gastrin-releasing peptide receptor (GRPR) in prostate cancer suggests that this re...
The gastrin-releasing peptide receptor (GRPR/BB2) is a molecular target for the visualization of pro...
The gastrin-releasing peptide receptor (GRPR/BB2) is a molecular target for the visualization of pro...
Expression of the gastrin-releasing peptide receptor (GRPR) in prostate cancer suggests that this re...
Radiolabelled antagonistic bombesin analogues are successfully used for targeting of gastrin-releasi...
Radiolabelled antagonistic bombesin analogues are successfully used for targeting of gastrin-releasi...
This thesis is focused on the development, preclinical evaluation, and optimization of radiotracers ...
Item does not contain fulltextThe gastrin-releasing peptide receptor (GRPR) is overexpressed in huma...
Gastrin-releasing peptide receptors (GRPrs) are overexpressed on a variety of human cancers, providi...
Gastrin-releasing peptide receptors (GRPrs) are overexpressed on a variety of human cancers, providi...
The overexpression of gastrin-releasing peptide receptor (GRPR) in cancer can be used for peptide-re...
The overexpression of gastrin-releasing peptide receptor (GRPR) in cancer can be used for peptide-re...
The overexpression of gastrin-releasing peptide receptor (GRPR) in cancer can be used for peptide-re...
INTRODUCTION The gastrin-releasing peptide receptor (GRPR) was shown to be expressed with high de...
Expression of the gastrin-releasing peptide receptor (GRPR) in prostate cancer suggests that this re...
Expression of the gastrin-releasing peptide receptor (GRPR) in prostate cancer suggests that this re...
The gastrin-releasing peptide receptor (GRPR/BB2) is a molecular target for the visualization of pro...
The gastrin-releasing peptide receptor (GRPR/BB2) is a molecular target for the visualization of pro...
Expression of the gastrin-releasing peptide receptor (GRPR) in prostate cancer suggests that this re...
Radiolabelled antagonistic bombesin analogues are successfully used for targeting of gastrin-releasi...
Radiolabelled antagonistic bombesin analogues are successfully used for targeting of gastrin-releasi...
This thesis is focused on the development, preclinical evaluation, and optimization of radiotracers ...
Item does not contain fulltextThe gastrin-releasing peptide receptor (GRPR) is overexpressed in huma...
Gastrin-releasing peptide receptors (GRPrs) are overexpressed on a variety of human cancers, providi...
Gastrin-releasing peptide receptors (GRPrs) are overexpressed on a variety of human cancers, providi...