Recent studies suggest that metformin, a widely used antidiabetic agent, may reduce cancer risk and improve prognosis of certain malignancies. However, the mechanisms for the anti-cancer effects of metformin remain uncertain. In this study, we investigated the effects of metformin on human bladder cancer cells and the underlying mechanisms. Metformin significantly inhibited the proliferation and colony formation of 5637 and T24 cells in vitro; specifically, metformin induced an apparent cell cycle arrest in G0/G1 phases, accompanied by a strong decrease of cyclin D1, cyclin-dependent kinase 4 (CDK4), E2F1 and an increase of p21waf-1. Further experiments revealed that metformin activated AMP-activated protein kinase (AMPK) and suppressed m...
Metformin is widely used in the treatment of diabetes mellitus type 2 where it reduces insulin resis...
Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association with i...
Metformin is an anti-hyperglycemic biguanide drug that is widely used as the first-line prescription...
International audienceMetformin is a widely used antidiabetic agent, which regulates glucose homeost...
Abstract: Recent studies suggest that metformin, a widely used antidiabetic agent, may reduce cancer...
Metformin has been widely used as an oral drug for diabetes mellitus for approximately 60 years. Int...
The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus, drugs ta...
Epidemiology studies have found that type 2 diabetics treated with metformin are at a lower risk for...
Panobinostat, a histone deacetylase inhibitor, induces histone acetylation and acts against cancer b...
Recent population studies provide clues that the use of metformin may be associated with reduced inc...
National science and technology special foundation for major infectious diseases prevention and cont...
Abstract Background Metformin, which is widely used as an antidiabetic agent, has recently been repo...
Metformin is widely used in the treatment of diabetes mellitus type 2 where it reduces insulin resis...
Metformin is the most used drug for type 2 diabetes (T2DM). Its antitumor activity has been describe...
Background. Medullary thyroid cancer (MTC) is associated with activation of mTOR signaling pathways....
Metformin is widely used in the treatment of diabetes mellitus type 2 where it reduces insulin resis...
Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association with i...
Metformin is an anti-hyperglycemic biguanide drug that is widely used as the first-line prescription...
International audienceMetformin is a widely used antidiabetic agent, which regulates glucose homeost...
Abstract: Recent studies suggest that metformin, a widely used antidiabetic agent, may reduce cancer...
Metformin has been widely used as an oral drug for diabetes mellitus for approximately 60 years. Int...
The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus, drugs ta...
Epidemiology studies have found that type 2 diabetics treated with metformin are at a lower risk for...
Panobinostat, a histone deacetylase inhibitor, induces histone acetylation and acts against cancer b...
Recent population studies provide clues that the use of metformin may be associated with reduced inc...
National science and technology special foundation for major infectious diseases prevention and cont...
Abstract Background Metformin, which is widely used as an antidiabetic agent, has recently been repo...
Metformin is widely used in the treatment of diabetes mellitus type 2 where it reduces insulin resis...
Metformin is the most used drug for type 2 diabetes (T2DM). Its antitumor activity has been describe...
Background. Medullary thyroid cancer (MTC) is associated with activation of mTOR signaling pathways....
Metformin is widely used in the treatment of diabetes mellitus type 2 where it reduces insulin resis...
Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association with i...
Metformin is an anti-hyperglycemic biguanide drug that is widely used as the first-line prescription...