PHARMACOKINETICS OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS

Pharmacokinetics of NSAIDS is relevant both for therapeutic and side effects especially with regard in "A" type of side effects and in their incidence. It is observed that NSAIDs reach high concentrations in body compartments in which cause therapeutic or unwanted effects, and therefore it is important to know pharmacokinetics of these drugs. The four phases of pharmacokinetics are explained, and the differences within different drugs are reported. It is important to note that from there differences it should be possible avoid known side effects or minimize it by using an appropriate drug dispensation regimen. Finally the investigation of these pharmacokinetic parameters could lead to develop better drugs as well to avoid accidents with new compounds extensively employed in clinical practice