Ginsenoside Rh2 (G-Rh2) has been shown to induce apoptotic cell death in a variety of cancer cells. However, the details of the signal transduction cascade involved in G-Rh2-induced cell death is unclear. In this manuscript we elucidate the molecular mechanism of G-Rh2-induced apoptosis in human hepatoma SK-HEP-1 cells by demonstrating that G-Rh2 causes rapid and dramatic translocation of both Bak and Bax, which subsequently triggers mitochondrial cytochrome c release and consequent caspase activation. Interestingly, siRNA-based gene inactivation of caspase-8 effectively delays caspase-9 activation and apoptosis induced by G-Rh2, indicating that caspase-8 also plays an important role in the G-Rh2-induced apoptosis program. Taken together, o...
Background and purpose: Lipid rafts and caveolae are membrane microdomains with important roles in c...
Recently, a novel intestinal bacterial metabolite of ginseng protopanaxadiol saponins, i.e., 20-0-(b...
Compound K (20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol) is an active metabolite of ginseno...
Ginsenoside Rh2 (G-Rh2), a rare ginsenoside isolated from red ginseng, has considerable anti-cancer ...
[[abstract]]Ginsenoside Rh2 (Rh2), a purified ginseng saponin, has been shown to have antiproliferat...
Ginsenoside Rk1 and Rg5 are minor ginseng saponins that have received more attention recently becaus...
Ginsenoside Rh2 is a potential pharmacologically active metabolite of ginseng. Previously, we have r...
Cervical cancer is a common gynecological malignancy afflicting women all over the world. Ginsenosid...
(20S) ginsenoside Rh2 (G-Rh2), a major bioactive metabolite of ginseng, effectively inhibits the sur...
Ginseng saponins exert various important pharmacological effects with regard to the control of many ...
The ginsenoside compound K (20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol; CK) is an intestinal...
Ginsenosides are major pharmaceutical components in ginseng, cytotoxicity of ginsenoside Rh2, which ...
Acute myeloid leukemia (AML) and Chronic myelogenous leukemia (CML) are common leukemia in adults. 2...
To investigate the role of mitochondria in the protective effects of ginsenoside Rb1 on cellular apo...
Background. Cisplatin is widely used in the treatment of malignant patients; however, its adverse ne...
Background and purpose: Lipid rafts and caveolae are membrane microdomains with important roles in c...
Recently, a novel intestinal bacterial metabolite of ginseng protopanaxadiol saponins, i.e., 20-0-(b...
Compound K (20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol) is an active metabolite of ginseno...
Ginsenoside Rh2 (G-Rh2), a rare ginsenoside isolated from red ginseng, has considerable anti-cancer ...
[[abstract]]Ginsenoside Rh2 (Rh2), a purified ginseng saponin, has been shown to have antiproliferat...
Ginsenoside Rk1 and Rg5 are minor ginseng saponins that have received more attention recently becaus...
Ginsenoside Rh2 is a potential pharmacologically active metabolite of ginseng. Previously, we have r...
Cervical cancer is a common gynecological malignancy afflicting women all over the world. Ginsenosid...
(20S) ginsenoside Rh2 (G-Rh2), a major bioactive metabolite of ginseng, effectively inhibits the sur...
Ginseng saponins exert various important pharmacological effects with regard to the control of many ...
The ginsenoside compound K (20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol; CK) is an intestinal...
Ginsenosides are major pharmaceutical components in ginseng, cytotoxicity of ginsenoside Rh2, which ...
Acute myeloid leukemia (AML) and Chronic myelogenous leukemia (CML) are common leukemia in adults. 2...
To investigate the role of mitochondria in the protective effects of ginsenoside Rb1 on cellular apo...
Background. Cisplatin is widely used in the treatment of malignant patients; however, its adverse ne...
Background and purpose: Lipid rafts and caveolae are membrane microdomains with important roles in c...
Recently, a novel intestinal bacterial metabolite of ginseng protopanaxadiol saponins, i.e., 20-0-(b...
Compound K (20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol) is an active metabolite of ginseno...