A route for the preparation of 2,5-disubstituted octahydroquinolin-4-ones, synthetic precursors of the decahydroquinoline-type toxins, is presented. The key steps are an asymmetric epoxidation and an intramolecular hetero Diels-Alder reaction between an activated diene and an imine. The presence of an allylic stereogenic center induces some selectivity and thus only two cycloadducts are obtained in 70:30 ratio and good yield
3-Methylenequinolin-2,4-dione generated in situ by Knoevenagel condensation of 4-hydroxyquinoline wi...
The synthesis of alkyl 2-(4-hydroxyquinolin-2-yl) acetates and 1-phenyl-4-(phenylamino)pyridine-2,6(...
Starting from 4-substituted cyclohexanones, a practical synthetic route to enantiopure 6-substituted...
A practical synthetic route to enantiopure 5-substituted cisdecahydroquinolines has been developed, ...
In the cycloaddition approach towards the synthesis of the substituted anthraquinone derivative 8 as...
Diels-Alder reactions in the 2,3,4,4a-tetrahydroquinolines series were studied for the first time. I...
The intramolecular Diels - Alder reaction of readily accessible 4-substituted 4-(N-furfuryl)aminobut...
The straightforward enantioselective construction of the hydroquinoline ring system from 1,5-polycar...
N-Acyl-N-(4-penten-1-yl)-1-amino-1, 3-butadiene (1) isomerisieren sich bei 190-215° über eine intram...
The straight forward synthesis of new carboxylic acids with hexahydro-oxaisoindolo[2.1-a]quinoline c...
A trienamine-mediated asymmetric Diels–Alder reaction using a 5-nitro-2,3-dihydro-4-pyridone derivat...
The development of a general strategy for the construction of anthracyclinones based on a Diels-Alde...
Asymmetric synthesis of dihydroquinolines by addition of organometallic reagents on a chiral 3-quino...
This thesis generalises the earlier reported one pot synthesis of 1,2,3,4-tetrahydroquinoline deriva...
Quinoline forms 1,4-zwitterion with dimethyl acetylenedicarboxylate, which is trapped by various dip...
3-Methylenequinolin-2,4-dione generated in situ by Knoevenagel condensation of 4-hydroxyquinoline wi...
The synthesis of alkyl 2-(4-hydroxyquinolin-2-yl) acetates and 1-phenyl-4-(phenylamino)pyridine-2,6(...
Starting from 4-substituted cyclohexanones, a practical synthetic route to enantiopure 6-substituted...
A practical synthetic route to enantiopure 5-substituted cisdecahydroquinolines has been developed, ...
In the cycloaddition approach towards the synthesis of the substituted anthraquinone derivative 8 as...
Diels-Alder reactions in the 2,3,4,4a-tetrahydroquinolines series were studied for the first time. I...
The intramolecular Diels - Alder reaction of readily accessible 4-substituted 4-(N-furfuryl)aminobut...
The straightforward enantioselective construction of the hydroquinoline ring system from 1,5-polycar...
N-Acyl-N-(4-penten-1-yl)-1-amino-1, 3-butadiene (1) isomerisieren sich bei 190-215° über eine intram...
The straight forward synthesis of new carboxylic acids with hexahydro-oxaisoindolo[2.1-a]quinoline c...
A trienamine-mediated asymmetric Diels–Alder reaction using a 5-nitro-2,3-dihydro-4-pyridone derivat...
The development of a general strategy for the construction of anthracyclinones based on a Diels-Alde...
Asymmetric synthesis of dihydroquinolines by addition of organometallic reagents on a chiral 3-quino...
This thesis generalises the earlier reported one pot synthesis of 1,2,3,4-tetrahydroquinoline deriva...
Quinoline forms 1,4-zwitterion with dimethyl acetylenedicarboxylate, which is trapped by various dip...
3-Methylenequinolin-2,4-dione generated in situ by Knoevenagel condensation of 4-hydroxyquinoline wi...
The synthesis of alkyl 2-(4-hydroxyquinolin-2-yl) acetates and 1-phenyl-4-(phenylamino)pyridine-2,6(...
Starting from 4-substituted cyclohexanones, a practical synthetic route to enantiopure 6-substituted...