Add to ORKGThe synthesis of isomuscarine (lI c) and ol its threeisomers is described. Their structure were establisked on the basis olN.M.R. and I.R. data.unlike the dioxolane (l), lrom which they are lormally derived bysubstituting the oxygen in position 3 by a CHOH group, the isomuscarinesare completely devoid of cholinergic activity. This result is explained bythe impossibility ol the corresponding receptor site of accepting a grouplarger than the ether oxygen. Interactions ol the onium and C-7 methylgroups are assumed to be the driving lorces for binding with the muscarinicreceptor while a dipole-dipole interaction for oxygenated functions is propose
The synthesis of the two pairs of enantiomers of methylenemuscarones 3 and 4 has been accomplishe...
A series of 1,3-dioxolane-based ligands, bearing hydroxymethyl or ester functionalities, was synthes...
Novel analogues of cis-N,N,N-trimethyl-(6-methyl-1,4-dioxan-2-yl)methanaminium iodide (2a) were synt...
The synthesis of isomuscarine (lI c) and ol its threeisomers is described. Their structure were esta...
To investigate further the nature of the active sites olcholinergic reeptors the carbocyclic analogs...
Several ethers and acetylderivatives of deoxamuscorine(l) and its isomers have been synthesized and ...
To elucidate the molecular requirements of the activesites of cholinergic receptors, 3-methyl-4-oxo-...
Some cyclopentene derivatives lacking the oxygenatedlunctions have been sltnthesized and tested as c...
In order to study the cholinergic receptor through affinitychromatography, some derivatives ol deoxa...
Five new analogs of muscarone were synthesized in order to evaluate the influence of the carbonyl gr...
In order to get infolmation on the molecular requirements of the cholinergic receptor, pure cis and,...
Four out of the eight possible stereoisomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine, ...
A series of rigid compounds - derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine me...
The deoxamuscarine analogs 4-6 were synthesized and their biological profiles at muscarinic subtypes...
To acquire more information about the so-called "muscarinic subsite", compound 4 was synthesized and...
The synthesis of the two pairs of enantiomers of methylenemuscarones 3 and 4 has been accomplishe...
A series of 1,3-dioxolane-based ligands, bearing hydroxymethyl or ester functionalities, was synthes...
Novel analogues of cis-N,N,N-trimethyl-(6-methyl-1,4-dioxan-2-yl)methanaminium iodide (2a) were synt...
The synthesis of isomuscarine (lI c) and ol its threeisomers is described. Their structure were esta...
To investigate further the nature of the active sites olcholinergic reeptors the carbocyclic analogs...
Several ethers and acetylderivatives of deoxamuscorine(l) and its isomers have been synthesized and ...
To elucidate the molecular requirements of the activesites of cholinergic receptors, 3-methyl-4-oxo-...
Some cyclopentene derivatives lacking the oxygenatedlunctions have been sltnthesized and tested as c...
In order to study the cholinergic receptor through affinitychromatography, some derivatives ol deoxa...
Five new analogs of muscarone were synthesized in order to evaluate the influence of the carbonyl gr...
In order to get infolmation on the molecular requirements of the cholinergic receptor, pure cis and,...
Four out of the eight possible stereoisomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine, ...
A series of rigid compounds - derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine me...
The deoxamuscarine analogs 4-6 were synthesized and their biological profiles at muscarinic subtypes...
To acquire more information about the so-called "muscarinic subsite", compound 4 was synthesized and...
The synthesis of the two pairs of enantiomers of methylenemuscarones 3 and 4 has been accomplishe...
A series of 1,3-dioxolane-based ligands, bearing hydroxymethyl or ester functionalities, was synthes...
Novel analogues of cis-N,N,N-trimethyl-(6-methyl-1,4-dioxan-2-yl)methanaminium iodide (2a) were synt...