Add to ORKGTo investigate further the nature of the active sites olcholinergic reeptors the carbocyclic analogs of isomuscarone and isomuscarine were synthesized- and tested for their cholinergicactivity.Like isomuscarines, such compounds are completely devoid of muscarinic activity which further support the hypothesis that the receptor site,corresponding to position 2 of the ring, cannot accept groups larger than and/or with a dipole having a different direction from that of an etheroxygen.on the other hand nicotinic activity is quite good. In this respectcompound (IV) is particulary interesting, being as actiie as ACh and pratically devoid of muscarinic aciivity
The muscarinic pharmacology of C1-methyl-substituted chiral compounds related to McN-A-343 and of (R...
The aim of this dissertation was to examine the hypothesis that (R)-nipecotic acid ethyl ester ((R)-...
A review is given of current, mostly biochemical, research on the muscarinic and the nicotinic acety...
To investigate further the nature of the active sites olcholinergic reeptors the carbocyclic analogs...
The synthesis of isomuscarine (lI c) and ol its threeisomers is described. Their structure were esta...
In order to study the cholinergic receptor through affinitychromatography, some derivatives ol deoxa...
To elucidate the molecular requirements of the activesites of cholinergic receptors, 3-methyl-4-oxo-...
Some cyclopentene derivatives lacking the oxygenatedlunctions have been sltnthesized and tested as c...
Several ethers and acetylderivatives of deoxamuscorine(l) and its isomers have been synthesized and ...
A series of acetylcholine carbamoyl analogues, cyclised at the carbamate moiety or at the cationic h...
In order to get infolmation on the molecular requirements of the cholinergic receptor, pure cis and,...
Four out of the eight possible stereoisomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine, ...
Five new analogs of muscarone were synthesized in order to evaluate the influence of the carbonyl gr...
A protocol for predicting full agonist, partial agonist, and antagonist profiles of compounds with M...
In this paper we describe the results obtained in the last few years studyingstructure-activity rela...
The muscarinic pharmacology of C1-methyl-substituted chiral compounds related to McN-A-343 and of (R...
The aim of this dissertation was to examine the hypothesis that (R)-nipecotic acid ethyl ester ((R)-...
A review is given of current, mostly biochemical, research on the muscarinic and the nicotinic acety...
To investigate further the nature of the active sites olcholinergic reeptors the carbocyclic analogs...
The synthesis of isomuscarine (lI c) and ol its threeisomers is described. Their structure were esta...
In order to study the cholinergic receptor through affinitychromatography, some derivatives ol deoxa...
To elucidate the molecular requirements of the activesites of cholinergic receptors, 3-methyl-4-oxo-...
Some cyclopentene derivatives lacking the oxygenatedlunctions have been sltnthesized and tested as c...
Several ethers and acetylderivatives of deoxamuscorine(l) and its isomers have been synthesized and ...
A series of acetylcholine carbamoyl analogues, cyclised at the carbamate moiety or at the cationic h...
In order to get infolmation on the molecular requirements of the cholinergic receptor, pure cis and,...
Four out of the eight possible stereoisomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine, ...
Five new analogs of muscarone were synthesized in order to evaluate the influence of the carbonyl gr...
A protocol for predicting full agonist, partial agonist, and antagonist profiles of compounds with M...
In this paper we describe the results obtained in the last few years studyingstructure-activity rela...
The muscarinic pharmacology of C1-methyl-substituted chiral compounds related to McN-A-343 and of (R...
The aim of this dissertation was to examine the hypothesis that (R)-nipecotic acid ethyl ester ((R)-...
A review is given of current, mostly biochemical, research on the muscarinic and the nicotinic acety...