Chiral tetramine disulfldes 3, designed to study the molecular properties of the active site of the adrenergic alpha-receptor, were synthesizedand tested on ral vas deferens preparation. The activity of the three optical isomers showed that the receptor displays an insignificantdegree ol stereoselectivity thus supporting the hypothesis that the benzylic groups of tetramine disulfides related to Benextramine donot bind at the same site that is normally occupied by the catechol nuclei of the neurotrirnsmitter. Rather, they would interact withan accessory area which appears to be insensitive to chirality efiects
Chirality plays an essential role in biological molecular recognition, such as neurotransmission. He...
In the present study, more than 75 compounds structurally related to BMY 7378 have been designed and...
This study describes the use of a naphtyl moiety as a probe to find out the steric differences in th...
Chiral tetramine disulfldes 3, designed to study the molecular properties of the active site of the ...
structure actiuity relationship studies previously led tothe discovery of two distinct classes of te...
"The recently reportod tetramine disu fides class of irreversible antagonists show a remarkable topo...
Symmetrical tetramine disulfides carrying on the terminal nitrogens one of the two moieties of WB 41...
Until recently, it has been tacitly assurned that the postsynaptic or alpha1-adrenoreceptors of dive...
Several N,”’-(dithiodi-2,1-ethanediyl) bis~N’-(arylmethyl)-l,6-hexanediaminewse]r e prepared and eva...
Polyaminedisulfides represent a novel class of irreversible (non-equilibrium) antagonists of thealph...
Several N,N'’-(dithiodi-2,1-ethanediyl)bis[N’-(arylmethyl)-1,6-hexanediamines] were prepared and eva...
The optical isomers of the well known alpha(1) - antagonist WB4101 and of its derivatives with a met...
The optical isomers of the well known \u3b11-antagonist WB4101 and of its derivatives with a methyl ...
Several N'-substituted N,N"-(dithiodi-2,1-ethanediyl)bis(1,w-alkanediamines) were prepared and evalu...
In the present study, more than 75 compounds structurally related to BMY 7378 have been designed and...
Chirality plays an essential role in biological molecular recognition, such as neurotransmission. He...
In the present study, more than 75 compounds structurally related to BMY 7378 have been designed and...
This study describes the use of a naphtyl moiety as a probe to find out the steric differences in th...
Chiral tetramine disulfldes 3, designed to study the molecular properties of the active site of the ...
structure actiuity relationship studies previously led tothe discovery of two distinct classes of te...
"The recently reportod tetramine disu fides class of irreversible antagonists show a remarkable topo...
Symmetrical tetramine disulfides carrying on the terminal nitrogens one of the two moieties of WB 41...
Until recently, it has been tacitly assurned that the postsynaptic or alpha1-adrenoreceptors of dive...
Several N,”’-(dithiodi-2,1-ethanediyl) bis~N’-(arylmethyl)-l,6-hexanediaminewse]r e prepared and eva...
Polyaminedisulfides represent a novel class of irreversible (non-equilibrium) antagonists of thealph...
Several N,N'’-(dithiodi-2,1-ethanediyl)bis[N’-(arylmethyl)-1,6-hexanediamines] were prepared and eva...
The optical isomers of the well known alpha(1) - antagonist WB4101 and of its derivatives with a met...
The optical isomers of the well known \u3b11-antagonist WB4101 and of its derivatives with a methyl ...
Several N'-substituted N,N"-(dithiodi-2,1-ethanediyl)bis(1,w-alkanediamines) were prepared and evalu...
In the present study, more than 75 compounds structurally related to BMY 7378 have been designed and...
Chirality plays an essential role in biological molecular recognition, such as neurotransmission. He...
In the present study, more than 75 compounds structurally related to BMY 7378 have been designed and...
This study describes the use of a naphtyl moiety as a probe to find out the steric differences in th...